CHRONIC INFLAMMATION AT ORAL AND CERVICO-VAGINAL MUCOSA

口腔和宫颈阴道粘膜的慢性炎症

• 批准号: 8168482
• 负责人: KRISTIN ASHFORD
• 金额: $ 29.5万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168482
• 关键词: African American; Anxiety; Biological Markers; Biological Markers; Birth; Caucasians; Caucasoid Race; Chronic; Computer Retrieval of Information on Scientific Projects Database; Cotinine; Coupled; Early treatment; Economics; Funding; Grant; Hispanics; Incidence; Inflammation; Inflammatory; Institution; Investigation; Latino; Link; Low Birth Weight Infant; Minority Groups; Mucous Membrane; Oral; Outcome; Patient Self-Report; Population; Population Heterogeneity; Predictive Value; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Process; Research; Research Personnel; Resources; Risk; Risk Factors; Rural; Saliva; Sampling; Serum; Source; Stress; Testing; Underserved Population; United States National Institutes of Health; Urine; Vagina; Woman; base; biobehavior; cost; depressive symptoms; experience; inflammatory marker; prenatal; psychosocial; racial and ethnic; vaginal fluid

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Preterm birth (PTB; 37 weeks gestation) and low birthweight (LBW; 2,500 g) deliveries continue to increase in the U.S. resulting in substantial economic and societal costs. Adverse pregnancy outcomes are disproportionately expressed in ethnic and racial minority populations and historically underserved populations, particularly from rural regions of the nation. However, a substantial proportion of the general overall increase in incidence of PTB and LBW, including severe PTB (32 weeks) and very low birthweight (1,500 g), cannot be explained by classical risk factors for these negative birth outcomes. Thus, a broader view of the potential interrelationships leading to adverse pregnancy outcomes, including biologic markers or processes could provide some predictive value allowing earlier intervention to reduce this burden in the population. This investigation will test the General Hypothesis that "women who deliver preterm will have higher levels of prenatal inflammatory markers in whole saliva, serum and cervico-vaginal fluid (CVF), which are displayed earlier in pregnancy compared to women who deliver term". Three specific aims will be used to guide the study in testing this hypothesis: Specific Aim 1: To compare and contrast the expression of trimester-specific prenatal inflammatory markers in whole saliva, serum and CVF. Rationale: This aim will determine our ability of detect trimester-specific inflammatory markers in saliva, serum, and CVF. Specific Aim 2: To define the differences in the expression of trimester-specific prenatal inflammatory markers between women who do and do not experience preterm birth in a multi-racial/ethnic population. Rationale: This aim will establish PTB-specific risk factors based on prenatal inflammatory biomarker profiles in a racially/ethnically diverse population of Caucasian, African American and Hispanic/Latino women) and preterm birth (37 completed weeks of gestation). Specific Aim 3: To determine if trimester-specific prenatal inflammatory markers linked with psychosocial and biobehavioral variables pose a significant risk for preterm birth in a multi-racial/ethnic sample of pregnant women. Rationale: This aim will establish if trimester-specific systemic and local prenatal markers of inflammation coupled with psychosocial and biobehavioral variables impact preterm birth risk and self-reported levels of prenatal depressive symptoms; anxiety; stress, urine cotinine, and self-reported prenatal SHS exposure

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在美国，早产(PTB；怀孕37周)和低出生体重(LBW；2,500克)分娩继续增加，造成了巨大的经济和社会成本。不良妊娠结局在少数民族和种族人口以及历来服务不足的人群中表现得不成比例，特别是在国家的农村地区。然而，肺结核和LBW发病率总体增加的很大一部分，包括严重的肺结核(32周)和非常低的出生体重(1500克)，不能用这些负面出生结果的传统风险因素来解释。因此，更广泛地看待导致不良妊娠结局的潜在相互关系，包括生物标志物或过程，可以提供一些预测价值，从而允许早期干预以减轻人口中的这一负担。这项调查将检验“早产妇女的全唾液、血清和宫颈阴道液(CVF)中的产前炎症标志物水平高于足月分娩妇女的普遍假设，这些指标在怀孕期间表现得更早”。在验证这一假说时，将使用三个特定目标来指导研究：特定目标1：比较和对比妊娠特异性产前炎症标志物在全唾液、血清和CVF中的表达。理论基础：这个目标将决定我们检测唾液、血清和CVF中三个月特异性炎症标志物的能力。具体目标2：确定在多种族/民族人群中有早产和没有早产的妇女之间三个月特异的产前炎症标志物表达的差异。理论基础：这一目标将根据种族/民族多样化的高加索人、非裔美国人和西班牙裔/拉丁裔妇女(包括高加索人、非裔美国人和西班牙裔/拉丁裔妇女)和早产(37周妊娠已完成)中的产前炎症生物标记物概况，确定肺结核特有的风险因素。具体目标3：在多种族/民族的孕妇样本中，确定与心理社会和生物行为变量相关的妊娠特异性产前炎症标记物是否对早产有显著风险。理论基础：这一目标将确定孕期特有的全身和局部产前炎症标志物，加上心理社会和生物行为变量，是否影响早产风险和自我报告的产前抑郁症状、焦虑、压力、尿可替宁和自我报告的产前SHS暴露水平。