Investigation of the correlation between mechanical information and pathological information on plaque rupture using human carotid arteries obtained at autopsy

我们将与斑块一起形成的纤维帽与尸检中获得的人颈动脉和胸主动脉的正常区域进行了比较。纤维帽在单轴拉伸下，膨胀率显著降低，应力显著增加，这与胶原蛋白和ⅰ型胶原蛋白显著增加，弹性蛋白显著减少有关。通过对具有液体样脂质核心的颈动脉进行有限元分析，我们发现与血压相比，血压水平明显较低。我们还通过对环状冠状动脉中三层血管层的拉伸试验和对这些应力释放层的初始几何形状进行有限元分析，建立了对这些血管层的影响的评估。

We compared the fibrous caps, which develop with plaques, with normal regions for human carotid arteries and thoracic aortas obtained at autopsy. A significant decrease of distensibility and significant increase of stress under uniaxial stretch were observed in fibrous caps, which were correlated with a significant increase of collagen and collagen type I as well as a significant decrease of elastin. We showed a significantly low level of pressure compared to the blood pressure through a finite element analysis of a carotid artery with a liquid-like lipid core. We also established an evaluation of the effect of three vascular layers in a ring-shaped coronary artery by stretching test of these layers and by finite element analysis with the initial geometry of these stress-released layers.