Investigation of the correlation between mechanical information and pathological information on plaque rupture using human carotid arteries obtained at autopsy

我们将形成斑块的纤维帽与尸检获得的人颈动脉和胸主动脉的正常区域进行了比较。纤维帽在单轴拉伸下膨胀性显著降低，应力显著升高，与胶原和I型胶原含量显著增加，弹性蛋白含量显著降低有关。我们通过对颈动脉的有限元分析显示，与血压相比，我们的血压水平明显较低，颈动脉具有液状脂质核心。我们还通过对三层血管的拉伸试验和对这些应力释放层的初始几何形状的有限元分析，建立了对环状冠状动脉中三层血管的影响的评价。

We compared the fibrous caps, which develop with plaques, with normal regions for human carotid arteries and thoracic aortas obtained at autopsy. A significant decrease of distensibility and significant increase of stress under uniaxial stretch were observed in fibrous caps, which were correlated with a significant increase of collagen and collagen type I as well as a significant decrease of elastin. We showed a significantly low level of pressure compared to the blood pressure through a finite element analysis of a carotid artery with a liquid-like lipid core. We also established an evaluation of the effect of three vascular layers in a ring-shaped coronary artery by stretching test of these layers and by finite element analysis with the initial geometry of these stress-released layers.