Investigation of the correlation between mechanical information and pathological information on plaque rupture using human carotid arteries obtained at autopsy

我们比较了纤维帽，其中发展斑块，与正常区域的人颈动脉和胸部动脉瘤尸检获得。纤维帽在单轴拉伸下的扩张性显著降低，应力显著增加，这与胶原和I型胶原的显著增加以及弹性蛋白的显著减少相关。我们通过对具有液体状脂质核心的颈动脉的有限元分析，显示出与血压相比显著低水平的压力。我们还建立了一个评价的效果，三个血管层在环形冠状动脉的拉伸试验，这些层和有限元分析与这些应力释放层的初始几何形状。

We compared the fibrous caps, which develop with plaques, with normal regions for human carotid arteries and thoracic aortas obtained at autopsy. A significant decrease of distensibility and significant increase of stress under uniaxial stretch were observed in fibrous caps, which were correlated with a significant increase of collagen and collagen type I as well as a significant decrease of elastin. We showed a significantly low level of pressure compared to the blood pressure through a finite element analysis of a carotid artery with a liquid-like lipid core. We also established an evaluation of the effect of three vascular layers in a ring-shaped coronary artery by stretching test of these layers and by finite element analysis with the initial geometry of these stress-released layers.