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Investigation of the correlation between mechanical information and pathological information on plaque rupture using human carotid arteries obtained at autopsy

Investigation of the correlation between mechanical information and pathological information on plaque rupture using human carotid arteries obtained at autopsy
利用尸检获得的人颈动脉研究斑块破裂的机械信息和病理信息之间的相关性
批准号:
23560091
负责人:
YAMADA Hiroshi
金额:
$3.33万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

项目摘要

项目成果

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中文摘要
翻译
我们将与斑块一起形成的纤维帽与尸检中获得的人颈动脉和胸主动脉的正常区域进行了比较。纤维帽在单轴拉伸下,膨胀率显著降低,应力显著增加,这与胶原蛋白和ⅰ型胶原蛋白显著增加,弹性蛋白显著减少有关。通过对具有液体样脂质核心的颈动脉进行有限元分析,我们发现与血压相比,血压水平明显较低。我们还通过对环状冠状动脉中三层血管层的拉伸试验和对这些应力释放层的初始几何形状进行有限元分析,建立了对这些血管层的影响的评估。
英文摘要
We compared the fibrous caps, which develop with plaques, with normal regions for human carotid arteries and thoracic aortas obtained at autopsy. A significant decrease of distensibility and significant increase of stress under uniaxial stretch were observed in fibrous caps, which were correlated with a significant increase of collagen and collagen type I as well as a significant decrease of elastin. We showed a significantly low level of pressure compared to the blood pressure through a finite element analysis of a carotid artery with a liquid-like lipid core. We also established an evaluation of the effect of three vascular layers in a ring-shaped coronary artery by stretching test of these layers and by finite element analysis with the initial geometry of these stress-released layers.
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会议论文
大動脈線維被膜の単軸伸展下での変形挙動解析と力学特性の評価
主动脉纤维囊单轴拉伸变形行为分析及力学性能评价
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Yamada H, Sakata N, 山田宏, 山田宏, 山田宏]
通讯作者: 山田宏
Finite element analysis of a ring-shaped blood vessel using the mechanical properties of its intima and media
利用环形血管内膜和中膜的机械特性对环形血管进行有限元分析
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Yamada H, Sakata N, 山田宏, 山田宏, 山田宏, H. Esmaeili Monir, 山田宏, H. Esmaeili Monir]
通讯作者: H. Esmaeili Monir
残留応力を解放した環状血管壁に対する単軸伸展下での有限要素解析
残余应力释放的环形容器壁单轴延伸有限元分析
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Yamada H, Sakata N, 山田宏, 山田宏, 山田宏, H. Esmaeili Monir, 山田宏, H. Esmaeili Monir, 山田宏, 山田宏, 山田宏, 山田宏]
通讯作者: 山田宏
頸動脈剖検例における動脈硬化性及び正常内膜層の伸展性と組織学的特徴の評価
颈动脉尸检病例中动脉硬化和正常内膜层的扩张性和组织学特征的评估
DOI: --
发表时间: 2014
期刊:
影响因子: --
作者: [Yamada H, Sakata N, 山田宏, 山田宏]
通讯作者: 山田宏
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