REGULATION OF PLATELET FUNCTION BY GPIIB-IIIA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 受体的整合素家族的成员在诱导粘附中起关键作用，并且参与需要粘附诱导的细胞行为变化的许多事件。 例如，跨整联蛋白的信号传导涉及血管生成、发育、转移、炎症、伤口愈合和止血。 我们研究的总体目标是了解导致整合素活化和整合素诱导的细胞行为变化的信号通路。 预计这些研究将提供有关整合素双向信号传导机制的信息。此外，这些研究可能导致对整合素介导的功能（如血小板粘附和聚集、伤口愈合、血管生成、炎症、转移和细胞迁移）中涉及的关键机制的理解增加。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Members of the integrin family of receptors play a critical role in inducing adhesion and are involved in numerous events that require adhesion-induced changes in cell behavior. For example, signaling across integrins is involved in angiogenesis, development, metastasis, inflammation, wound healing, and hemostasis. The overall goal of our research is to understand the signaling pathways leading to integrin activation and to integrin-induced changes in cell behavior. It is anticipated that these studies will provide information on mechanisms involved in two-way signaling across integrins. Further, the studies may lead to an increased understanding of key mechanisms involved in integrin-mediated functions such as platelet adhesion and aggregation, wound healing, angiogenesis, inflammation, metastasis, and cell migration.