REGULATION OF PLATELET FUNCTION BY GPIIB-IIIA

GPIIB-IIIA 对血小板功能的调节

• 批准号: 7608180
• 负责人: JOAN E.B. FOX
• 金额: $ 0.47万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7608180
• 关键词: Adhesions; Blood Platelets; Computer Retrieval of Information on Scientific Projects Database; Development; Event; Family; Funding; Goals; Grant; Hemostatic function; Inflammation; Institution; Integrins; Lead; Mediating; Neoplasm Metastasis; Play; Regulation; Research; Research Personnel; Resources; Role; Signal Pathway; Signal Transduction; Source; United States National Institutes of Health; Wound Healing; angiogenesis; cell behavior; cell motility; member; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Members of the integrin family of receptors play a critical role in inducing adhesion and are involved in numerous events that require adhesion-induced changes in cell behavior. For example, signaling across integrins is involved in angiogenesis, development, metastasis, inflammation, wound healing, and hemostasis. The overall goal of our research is to understand the signaling pathways leading to integrin activation and to integrin-induced changes in cell behavior. It is anticipated that these studies will provide information on mechanisms involved in two-way signaling across integrins. Further, the studies may lead to an increased understanding of key mechanisms involved in integrin-mediated functions such as platelet adhesion and aggregation, wound healing, angiogenesis, inflammation, metastasis, and cell migration.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 整合素受体家族的成员在诱导粘附中发挥着关键作用，并参与许多需要粘附诱导的细胞行为变化的事件。 例如，整合素间的信号传导涉及血管生成、发育、转移、炎症、伤口愈合和止血。 我们研究的总体目标是了解导致整合素激活和整合素诱导的细胞行为变化的信号通路。 预计这些研究将提供有关整合素双向信号传导机制的信息。此外，这些研究可能会加深对整合素介导功能的关键机制的理解，例如血小板粘附和聚集、伤口愈合、血管生成、炎症、转移和细胞迁移。