EFFECT OF ORAL LEUCINE SUPPLEMENTATION ON PROTEIN SYNTHESIS IN TYPE 1 DIABETES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是确定氨基酸亮氨酸是否可以增强1型糖尿病儿童蛋白质代谢对喂养的合成代谢反应。在这项研究中，将比较喂食基于乳蛋白的口服饮食与喂食相同的口服饮食但添加亮氨酸的合成代谢作用。 从L-[1-13 C]亮氨酸的动力学评估亮氨酸对蛋白质代谢的急性作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine if the amino acid leucine can enhance the anabolic response of protein metabolism to feeding in children with type 1 diabetes. In this study the anabolic effect of feeding an oral diet based on milk protein will be compared with feeding the same oral diet but with additional leucine. The acute effect of leucine on protein metabolism will be assessed from the kinetics of L-[1-13 C] leucine.