EFFECT OF ORAL LEUCINE SUPPLEMENTATION ON PROTEIN SYNTHESIS IN TYPE 1 DIABETES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是确定氨基酸亮氨酸是否能增强1型糖尿病儿童对喂养的蛋白质代谢的合成代谢反应。在这项研究中，以牛奶蛋白为基础的口服饮食的合成代谢效果将与喂食相同的口服饮食但添加亮氨酸进行比较。亮氨酸对蛋白质代谢的急性影响将从L-[1-13C]亮氨酸的动力学来评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine if the amino acid leucine can enhance the anabolic response of protein metabolism to feeding in children with type 1 diabetes. In this study the anabolic effect of feeding an oral diet based on milk protein will be compared with feeding the same oral diet but with additional leucine. The acute effect of leucine on protein metabolism will be assessed from the kinetics of L-[1-13 C] leucine.