A BLINDED CONTROLLED STUDY OF ALENDRONATE IN CHRONIC SPINAL CORD INJURY

阿仑膦酸钠治疗慢性脊髓损伤的盲对照研究

• 批准号: 7608128
• 负责人: PETER H GORMAN
• 金额: $ 0.09万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7608128
• 关键词: Age; Alendronate; Blinded; Bone Density; Calcium; Chronic; Computer Retrieval of Information on Scientific Projects Database; Controlled Study; Devices; Double-Blind Method; Enrollment; Funding; Grant; Individual; Injury; Institution; Laboratories; Measurement; Participant; Pharmaceutical Preparations; Placebos; Population; Research; Research Personnel; Resources; Source; Spinal cord injury; Travel; United States National Institutes of Health; Visit; Vitamin D; Week; Wheelchairs; cost; day

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bone, Density is known to be compromised in the Spinal Cord Injured Population. This double-blind, placebo-comtrolled, single center trial will ascertain the ability of a medication called alendronate to increase or maintain the bone density of individuals with spinal cord injury who are at least 18 months past their injury. Participants should be between age 18 and 60 and must rely on a wheelchair for mobility. Participants will be asked over a one-year period to take calcium and Vitamin D supplements each day and to take alendronate (or placebo) once each week. Bone density measurements using an x-ray like device will be done at enrollment and repeated at 6 months and one year. Laboratory measurements will be made every three months over that year, and each measurement will require a visit to the GCRC lab at UMMS. Participants will receive a small stipend to cover their travel and other costs of participation.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 已知脊髓损伤人群的骨密度受到损害。 这项双盲、安慰剂对照、单中心试验将确定一种名为阿仑膦酸钠的药物是否有能力增加或维持脊髓损伤患者骨密度（受伤后至少 18 个月）。 参与者年龄应在 18 至 60 岁之间，并且必须依靠轮椅行动。 参与者将被要求在一年内每天服用钙和维生素 D 补充剂，并每周服用一次阿仑膦酸钠（或安慰剂）。 将在入组时使用类似 X 射线的设备进行骨密度测量，并在 6 个月和一年时重复测量。 实验室测量将在当年每三个月进行一次，每次测量都需要访问 UMMS 的 GCRC 实验室。 参与者将获得小额津贴，以支付他们的旅行和其他参与费用。