CUMC: PROTEOMICS

CUMC：蛋白质组学

• 批准号: 7627592
• 负责人: Sandor Lovas
• 金额: $ 8.41万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7627592
• 关键词: Agreement; American; Amyloid beta-Protein; Complex; Computer Retrieval of Information on Scientific Projects Database; Contract Services; Doctor of Philosophy; Faculty; Funding; Grant; Institution; Peptides; Property; Proteomics; Research; Research Personnel; Resources; SHFM1 gene; Science; Source; Spectrum Analysis; Structure; Students; Support of Research; Time; United States National Institutes of Health; Universities; instrument; symposium

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Proteomics Facility at the Department of Biomedical Sciences continued to serve faculty and students. The instruments are regularly maintained either on service contract or by the technician in the Facility. During the time 215 mass spectral analysis were performed. The ECD instrument was used to analyze conformational changes of amyloid beta peptide by Michael C. Owen Ph. D. student. Attila Borics Ph.D. student used the VCD to characterize beta-turn peptides. Jeffrey Copps Ph. D. student analyzed conformational properties of TC5b, a 20 residue peptide which is the shortest sequence showing cooperatively folded tertiary structure, by VCD spectroscopy and revealed a complex structure in agreement with NMR results. These results will be presented at the 19th American Peptide Symposium. The ECD instrument was also used to support the research of Guangshun Wang at UNMC, Richard Hallworth and Parick Swanson at Creighton University.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 生物医学科学系的蛋白质组学设施继续为教师和学生服务。 这些工具定期通过服务合同或设施中的技术人员维护。 在此期间进行215次质谱分析。 ECD仪器用于分析Michael C. OwenPh。D.Student的淀粉样蛋白β肽的构象变化。 Attila Borics博士学生使用VCD来表征β-转弯肽。 Jeffrey CoppsPh。D.学生分析了TC5B的构象性质，TC5B是20个残基肽，这是通过VCD光谱法，最短的序列显示了合作折叠的三级结构，并揭示了与NMR结果一致的复杂结构。 这些结果将在第19届美国肽研讨会上提出。 ECD仪器还用于支持Creighton University的UNMC，Richard Hallworth和Parick Swanson的Guangshun Wang的研究。