CUMC: PROTEOMICS

CUMC：蛋白质组学

• 批准号: 7627592
• 负责人: Sandor Lovas
• 金额: $ 8.41万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7627592
• 关键词: Agreement; American; Amyloid beta-Protein; Complex; Computer Retrieval of Information on Scientific Projects Database; Contract Services; Doctor of Philosophy; Faculty; Funding; Grant; Institution; Peptides; Property; Proteomics; Research; Research Personnel; Resources; SHFM1 gene; Science; Source; Spectrum Analysis; Structure; Students; Support of Research; Time; United States National Institutes of Health; Universities; instrument; symposium

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Proteomics Facility at the Department of Biomedical Sciences continued to serve faculty and students. The instruments are regularly maintained either on service contract or by the technician in the Facility. During the time 215 mass spectral analysis were performed. The ECD instrument was used to analyze conformational changes of amyloid beta peptide by Michael C. Owen Ph. D. student. Attila Borics Ph.D. student used the VCD to characterize beta-turn peptides. Jeffrey Copps Ph. D. student analyzed conformational properties of TC5b, a 20 residue peptide which is the shortest sequence showing cooperatively folded tertiary structure, by VCD spectroscopy and revealed a complex structure in agreement with NMR results. These results will be presented at the 19th American Peptide Symposium. The ECD instrument was also used to support the research of Guangshun Wang at UNMC, Richard Hallworth and Parick Swanson at Creighton University.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 生物医学科学系的蛋白质组学设施继续为教师和学生服务。 这些仪器由服务合同或工厂的技术人员定期维护。 在此期间，进行了215次质谱分析。 用电化学检测仪分析淀粉样β肽的构象变化。欧文博士学生. Attila Borics博士学生使用VCD来表征β-转角肽。 杰弗里·科普斯博士学生通过VCD光谱分析了TC 5 b（一种20个残基的肽，是显示协同折叠三级结构的最短序列）的构象特性，并揭示了与NMR结果一致的复杂结构。 这些结果将在第19届美国肽研讨会上发表。 ECD仪器还用于支持UNMC的Guangshun Wang，Creighton大学的Richard Hallworth和Parick Swanson的研究。