CUMC: PROTEOMICS

CUMC：蛋白质组学

• 批准号: 7381507
• 负责人: Sandor Lovas
• 金额: $ 8.66万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381507
• 关键词: CUMC; PROTEOMICS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Proteomics Facility at the Department of Biomedical Sciences continued to serve faculty and students. The instruments are regularly maintained either on service contract or by the technician in the Facility. During the time 215 mass spectral analysis were performed. The ECD instrument was used to analyze conformational changes of amyloid beta peptide by Michael C. Owen Ph. D. student. Attila Borics Ph.D. student used the VCD to characterize beta-turn peptides. Jeffrey Copps Ph. D. student analyzed conformational properties of TC5b, a 20 residue peptide which is the shortest sequence showing cooperatively folded tertiary structure, by VCD spectroscopy and revealed a complex structure in agreement with NMR results. These results will be presented at the 19th American Peptide Symposium. The ECD instrument was also used to support the research of Guangshun Wang at UNMC, Richard Hallworth and Parick Swanson at Creighton University.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。生物医学科学系的蛋白质组学设施继续为教师和学生服务。仪器根据服务合同或由工厂的技术人员定期维护。在此期间进行了215次质谱分析。本研究由Michael C. Owen博士研究生使用ECD仪器分析β淀粉样肽的构象变化。Attila Borics的博士生使用VCD来表征β -转肽类。Jeffrey Copps博士的学生利用VCD光谱分析了TC5b的构象性质，发现TC5b的结构与核磁共振结果一致。TC5b是一个20残基的肽，是显示合作折叠三级结构的最短序列。这些结果将在第19届美国多肽研讨会上发表。该ECD仪器还被用于支持UNMC的Guangshun Wang、Creighton大学的Richard Hallworth和Parick Swanson的研究。