MT COBRE: CORE FACILITY DEVELOPMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 科布雷项目的一个主要目标是通过开发核心设施，增加研究人员获得最先进设备的机会，从而提高研究竞争力。如我们的组织结构图所示，调查人员可以访问校园内急需的六个核心研究设施(CRF)。其中四个CRF由Cobre CSFN直接资助：质谱学和蛋白质组学、分子组织学和荧光成像、分子计算和建模以及生物光谱学。重要的是，这些CRF不仅得到了目前的科布尔奖的支持，还得到了大学研究办公室和蒙大拿州匹配基金的支持，以及NIH和NSF授予UM的赠款。合作伙伴关系框架继续发展，并按计划发挥作用，不仅加强个别项目，而且促进合作。这些核心产生的项目已开始出版出版物，并作为关键资源列入CSFN调查员资助的若干R01申请以及提交的申请中。在这方面应该指出的是，在几乎每一种情况下，提交的赠款(已评分和未评分)的RO1审查表继续将研究环境描述为非常支持拟议的项目。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A major goal of the COBRE project is to enhance research competitiveness by increasing the access investigators have to state-of-the-art equipment through the development of core facilities. As outlined on our organizational chart, investigators have access to six critically needed Core Research Facilities (CRFs) on campus. Four of these CRFs are directly funded by the COBRE CSFN: Mass Spectroscopy and Proteomics, Molecular Histology and Fluorescence Imaging, Molecular Computation and Modeling, and BioSpectroscopy. Importantly, these CRFs are supported not only by the present COBRE award, but also by the University Research Office and State of Montana match funding, as well as by NIH and NSF grants awarded to UM. The CRFs have continued to develop and, as planned, have served not only to enhance individual projects but also to promote collaborations. Projects emerging from these cores have begun to produce publications and to be included as a critical resource in a number of funded R01 applications by CSFN investigators as well as in submitted applications. It should be noted in this regard that in almost every instance the RO1 review sheets from submitted grants (scored and unscored) continue to characterize the research environment as very supportive of the proposed projects.