MT COBRE: CORE FACILITY DEVELOPMENT

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。科布雷项目的一个主要目标是通过开发核心设施，增加研究人员获得最先进设备的机会，从而提高研究竞争力。如我们的组织结构图所示，调查人员可以访问校园内急需的六个核心研究设施(CRF)。其中四个CRF由Cobre CSFN直接资助：质谱学和蛋白质组学、分子组织学和荧光成像、分子计算和建模以及生物光谱学。重要的是，这些CRF不仅得到了目前的科布尔奖的支持，还得到了大学研究办公室和蒙大拿州匹配基金的支持，以及NIH和NSF授予UM的赠款。合作伙伴关系框架继续发展，并按计划发挥作用，不仅加强个别项目，而且促进合作。这些核心产生的项目已开始出版出版物，并作为关键资源列入CSFN调查员资助的若干R01申请以及提交的申请中。在这方面应该指出的是，在几乎每一种情况下，提交的赠款(已评分和未评分)的RO1审查表继续将研究环境描述为非常支持拟议的项目。在过去的一年里，S的活动特别值得注意的是，制定了一项全大学范围的计划，以支持地方合作与发展基金。密歇根大学的调查人员和管理人员都有一个明确的共识，那就是所有核心的长期运营对于大学(和科布雷)在生物医学研究中建立有竞争力的项目的使命至关重要。人们也很容易承认，校园里调查人员的临界数量不太可能增长到这样的程度，即这些信托基金中的大多数仅凭使用费就能得到支持。因此，持续的支持将取决于一个多方面的战略，其中包括：基础设施赠款(例如，COBRE、EPSCoR)、国家匹配、个人RO1、多研究员赠款以及大学研究副总裁S办公室。还制定了一项管理计划。CRF的四名主任由一个指导委员会和咨询小组组成，其具体目标包括：(A)CSFN？研究圆桌会议；(B)预算；(C)CSFN报告职能；(D)整体设施整合和管理。除了四名董事外，Cobre PD(R Bridges)、研究副总裁(D Dwyer)、Cobre PD助理(K Stewart)和两名外部顾问成员将在负责财务、人员、报告和运营的指导委员会(季度会议)任职。该委员会最终将扩大到包括校园内的其他核心设施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A major goal of the COBRE project is to enhance research competitiveness by increasing the access investigators have to state-of-the-art equipment through the development of core facilities. As outlined on our organizational chart, investigators have access to six critically needed Core Research Facilities (CRFs) on campus. Four of these CRFs are directly funded by the COBRE CSFN: Mass Spectroscopy and Proteomics, Molecular Histology and Fluorescence Imaging, Molecular Computation and Modeling, and BioSpectroscopy. Importantly, these CRFs are supported not only by the present COBRE award, but also by the University Research Office and State of Montana match funding, as well as by NIH and NSF grants awarded to UM. The CRFs have continued to develop and, as planned, have served not only to enhance individual projects but also to promote collaborations. Projects emerging from these cores have begun to produce publications and to be included as a critical resource in a number of funded R01 applications by CSFN investigators as well as in submitted applications. It should be noted in this regard that in almost every instance the RO1 review sheets from submitted grants (scored and unscored) continue to characterize the research environment as very supportive of the proposed projects. Of particular note in regard to the past year¿s activity was the development of a University-wide plan to support CRFs. There is a clear consensus on the part of both UM investigators and administrators that the long-term operation of all of the Cores is critical to University's (and COBRE) mission of building competitive programs in biomedical research. It is also readily acknowledged that the critical mass of investigators on campus will not likely grow to such an extent that a majority of these CRFs can be supported solely on the basis of user fees. Thus, continued support will be dependent upon a multifaceted strategy that includes: infrastructure grants (e.g., COBRE, EPSCoR), State match, individual RO1s, multi-investigator grants, and the University¿s Office of the VP for Research. A management plan is also in place. The four CRF directors comprise a steering committee and advisory group with a number of specific goals including: (a) CSFN ¿research roundtable,¿ (b) budget, (c) CSFN reporting functions, and (d) overall facility integration and management. In addition to the four directors, the COBRE PD (R Bridges), the VP for Research, (D Dwyer), Asst to the COBRE PD (K Stewart), and two external advisory members will serve on the steering committee (quarterly meetings) that is responsible for the fiscal, staff, reporting and operations. This committee will eventually grow to include the other Core Facilities on campus.