Nuclear Receptors in Liver Health and Disease

肝脏健康和疾病中的核受体

基本信息

  • 批准号:
    7236612
  • 负责人:
  • 金额:
    $ 202.6万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2006
  • 资助国家:
    美国
  • 起止时间:
    2006-06-01 至 2011-04-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Five years of funding are requested to develop a Center of Biomedical Research Excellence at Kansas University Medical Center with a focus on Nuclear Receptors and their Role in Liver Health and Disease. Five talented new faculty who share this research interest were selected with the goal of helping them become funded, independent investigators. A PI, co-PI, an internal advisory committee of experienced senior faculty and an external advisory committee of prominent scientists have been assembled to mentor them to this goal. The Center will also help provide infrastructure and equipment to supplement the research environment. Ultimately, through the achievement of these initial goals, the final long-range goal is the submission of a program project grant application centered on the theme of nuclear receptors and related topics. An important feature of this Proposal is that for each initial junior faculty member, two co-mentors have been assigned and individual mentoring plans and timetables have been developed. Central features of the mentoring plans include ongoing critical evaluation of the research project by the mentors and IAC, semiannual conferences with EAC members, and special training on statistics, manuscript and grant writing, and teaching. The initial group will receive support for up to three years. Within this time period each member will be expected to compete successfully for independent NIH R01-type research support. Once funded externally, they will financially rotate off the grant to make room for addition of new junior faculty members. Over five years, the grant will support 10-15 independent research investigators. Another important feature of the Proposal is to establish five new Core capabilities to provide additional research support for the Center's faculty. These cores include an administrative Core as well as Cores in the areas of molecular biology, null-mice development and husbandry, phenotyping capabilities, and bioanalytical support. In summary, the outstanding combination of scientific talent, existing research environment, and requested new core facilities ensure that this proposed Center will foster the development of a thematic multi-disciplinary research center, to enhance the ability of new investigators to compete independently for complementary NIH and other external peer-reviewed support, and to strengthen existing biomedical research infrastructure at KUMC.
描述(由申请人提供): 五年的资金被要求在堪萨斯大学医学中心建立一个生物医学研究卓越中心,重点是核受体及其在肝脏健康和疾病中的作用。五个有才华的新教师谁分享这一研究兴趣被选中,帮助他们成为资助,独立的调查人员的目标。一个PI,共同PI,一个由经验丰富的高级教师组成的内部咨询委员会和一个由杰出科学家组成的外部咨询委员会已经成立,以指导他们实现这一目标。该中心还将帮助提供基础设施和设备,以补充研究环境。最终,通过实现这些初始目标,最终的长期目标是提交以核受体和相关主题为中心的计划项目资助申请。本提案的一个重要特点是,对于每个初始的初级教员,两个共同导师已被分配和个人辅导计划和时间表已制定。指导计划的主要特点包括导师和IAC对研究项目的持续批判性评估,与EAC成员的半年度会议,以及统计,手稿和赠款写作和教学方面的特殊培训。最初的小组将获得长达三年的支持。在这段时间内,每个成员将有望成功地竞争独立的NIH R 01型研究支持。一旦获得外部资助,他们将在财政上轮换赠款,为新的初级教师的增加腾出空间。在五年内,该赠款将支持10-15名独立研究人员。该提案的另一个重要特点是建立五个新的核心能力,为中心的教师提供额外的研究支持。这些核心包括管理核心以及分子生物学、裸小鼠开发和饲养、表型分析能力和生物分析支持领域的核心。总之,科学人才,现有的研究环境,并要求新的核心设施的杰出组合,确保这个拟议的中心将促进主题多学科研究中心的发展,以提高新的研究人员独立竞争的能力补充NIH和其他外部同行评审的支持,并加强现有的生物医学研究基础设施在KUMC。

项目成果

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CURTIS D KLAASSEN其他文献

CURTIS D KLAASSEN的其他文献

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{{ truncateString('CURTIS D KLAASSEN', 18)}}的其他基金

COBRE: U OF KANSAS MEDICAL CTR : CORE A: ADMINISTRATIVE CORE
COBRE:堪萨斯大学医学中心:核心 A:行政核心
  • 批准号:
    7610767
  • 财政年份:
    2007
  • 资助金额:
    $ 202.6万
  • 项目类别:
Nuclear Receptors in Liver Health and Disease
肝脏健康和疾病中的核受体
  • 批准号:
    6963316
  • 财政年份:
    2006
  • 资助金额:
    $ 202.6万
  • 项目类别:
COBRE: U OF KANSAS MEDICAL CTR : CORE A: ADMINISTRATIVE CORE
COBRE:堪萨斯大学医学中心:核心 A:行政核心
  • 批准号:
    7382246
  • 财政年份:
    2006
  • 资助金额:
    $ 202.6万
  • 项目类别:
Coordinate Regulation of Uptake and Efflux Transporters
摄取和流出转运蛋白的协调调节
  • 批准号:
    7030713
  • 财政年份:
    2006
  • 资助金额:
    $ 202.6万
  • 项目类别:
Coordinate Regulation of Uptake and Efflux Transporters
摄取和流出转运蛋白的协调调节
  • 批准号:
    7168010
  • 财政年份:
    2006
  • 资助金额:
    $ 202.6万
  • 项目类别:
REGULATION OF BILIARY EXCRETION OF XENOBIOTICS BY MRP2
MRP2 对异生物质胆汁排泄的调节
  • 批准号:
    6518139
  • 财政年份:
    2000
  • 资助金额:
    $ 202.6万
  • 项目类别:
REGULATION OF BILIARY EXCRETION OF XENOBIOTICS BY MRP2
MRP2 对异生物质胆汁排泄的调节
  • 批准号:
    6607711
  • 财政年份:
    2000
  • 资助金额:
    $ 202.6万
  • 项目类别:
Regulation of Hepatic Uptake of Drugs and Xenobiotics
药物和异生素的肝脏摄取调节
  • 批准号:
    7030423
  • 财政年份:
    2000
  • 资助金额:
    $ 202.6万
  • 项目类别:
Regulation of Hepatic Excretion of Xenobiotics by Mrps
Mrps 对异生物质肝脏排泄的调节
  • 批准号:
    7093310
  • 财政年份:
    2000
  • 资助金额:
    $ 202.6万
  • 项目类别:
REGULATION OF HEPATIC UPTAKE OF DRUGS AND XENOBIOTICS
药物和异生物质的肝脏摄取的调节
  • 批准号:
    6382269
  • 财政年份:
    2000
  • 资助金额:
    $ 202.6万
  • 项目类别:

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PPARa and related nuclear receptors in non-alcoholic fatty liver disease
PPARa 和相关核受体在非酒精性脂肪肝中的作用
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研究重点关注核受体 PXR 和 CAR 调节的肝脏成熟和肝功能的药物的下一代和迟发效应
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