CLAUDE D.PEPPER OLDER AMERICANS INDEPENDENCE CENTERS

描述（由申请人提供）：这是一个竞争性的更新申请，支持克劳德D。胡椒老年美国人独立中心（OAIC）在密歇根大学（UM胡椒中心）。UM Pepper中心的具体目标是：1）通过提高对衰老表型的预测因子和调节因子及其产生的健康结果的理解，支持专注于增强老年人独立性的研究。2)通过支持转化研究，将有关老龄化和导致残疾的老年人常见健康问题的基础和临床研究联系起来，帮助维持和恢复老年人的独立性。3)提供研究资源核心（RRC），支持和协助研究人员发起的研究项目，这些项目可以导致对导致老年人衰老表型和丧失独立性的基本机制的新见解，以及开发和测试适用于此类研究项目的创新方法的核心开发项目。4)通过其研究职业发展核心（RCDC），加强UM环境，培养未来的老年医学和老龄化学术领导者，他们可以对衰老表型的基本机制进行研究，可以开发新方法来加强转化研究，并可以进行有前途的干预措施的临床试验，以提高老年人的独立性。5)通过其试点和探索性研究核心（PESC），以吸引UM初级教师和高级教师以前没有参与老龄化研究，研究问题诱发衰老表型，并进行转化研究，以保持和提高老年人的独立性。 UM胡椒中心有一个完善的领导和行政结构，RCDC和PESC的关键要素，以及四个RRC，所有这些都是在UM胡椒中心的主持下组织和资助的。这些RRC包括人类受试者和评估核心（HSAC）;生物力学核心;方法，数据管理和分析核心（MDMAC）;以及老年啮齿动物核心设施（CFAR）。本申请提出了一种新的基因组分析核心（GAC）。六个核心发展项目将加强这些区域中心的活动。RCDC具有三个核心要素：1）一个有竞争力的计划，以选择有前途的UM初级教师的工资支持进行相关的研究UM胡椒中心的研究重点; 2）一个研究培训计划，为初级教师从事这样的研究，和3）一个导师计划，允许初级教师与一个或多个UM高级研究人员密切合作。

DESCRIPTION (provided by applicant): This is a competing renewal application for support of the Claude D. Pepper Older Americans Independence Center (OAIC) at the University of Michigan (UM Pepper Center). The specific aims of the UM Pepper Center are: 1) To support research which has a focus on enhancing the independence of older adults by improved understanding of predictors and modulators of the aging phenotype, and its resulting health outcomes. 2) To help maintain and restore the independence of older people by supporting translational research linking basic and clinical research on aging and common health problems of older adults leading to disability. 3) To provide Research Resources Cores (RRCs) that support and assist investigator initiated research projects which can lead to new insights into the basic mechanisms underlying conditions that contribute to the aging phenotype and loss of independence of older adults, and Core Development Projects which develop and test innovative methods to apply to such research projects. 4) Through its Research Career Development Core (RCDC), to strengthen the UM environment for training of future academic leaders in geriatrics and aging who can conduct research on basic mechanisms contributing to the aging phenotype, can develop new methods to enhance translational research, and can carry out clinical trials of promising interventions to enhance independence of older adults. 5) Through its Pilot and Exploratory Studies Core (PESC), to attract UM junior faculty and senior faculty not previously involved in aging research to study problems predisposing to the aging phenotype and to carry out translational research to maintain and enhance independence of older adults. The UM Pepper Center has in place a well established leadership and administrative structure, the key elements of the RCDC and the PESC, and four RRCs, all of which were organized and funded under the auspices of the UM Pepper Center during the previous 14 years. These RRC's include the Human Subjects and Assessment Core (HSAC); the Biomechanies Core; the Methodology, Data Management and Analysis Core (MDMAC); and the Core Facility for Aged Rodents (CFAR). A new Genomic Analysis Core (GAC) is proposed in this application. Six Core Development Projects will strengthen the activities of theses RRCs. The RCDC features three central elements: 1) a competitive program to select promising UM junior faculty for salary support to conduct research relevant to the UM Pepper Center's research focus; 2) a research training program for junior faculty engaged in such research, and 3) a Mentorship Program that permits junior faculty members to work closely with one or more UM senior investigators.