CLAUDE D.PEPPER OLDER AMERICANS INDEPENDENCE CENTERS

描述（由申请人提供）：这是一份为密歇根大学（UM Pepper中心）Claude D. Pepper老年美国人独立中心（OAIC）提供支持的竞争性续期申请。UM胡椒中心的具体目标是：1)支持通过提高对衰老表型的预测因子和调节因子及其产生的健康结果的理解来提高老年人独立性的研究。2)通过支持将老龄和导致残疾的老年人常见健康问题的基础和临床研究联系起来的转化研究，帮助维持和恢复老年人的独立性。3)提供研究资源核心（rrc），支持和协助研究者发起的研究项目，这些研究项目可能导致老年人衰老表型和独立性丧失的基本机制和条件的新见解，以及开发和测试适用于这些研究项目的创新方法的核心开发项目。4)通过其研究职业发展核心（RCDC），加强UM培养未来老年医学和老龄化学术领袖的环境，他们可以研究衰老表型的基本机制，可以开发新的方法来加强转化研究，可以开展有前途的干预措施的临床试验，以提高老年人的独立性。5)通过其试点和探索性研究核心（PESC），吸引澳大以前未参与老龄化研究的初级教师和高级教师研究易导致衰老表型的问题，并开展转化研究，以维持和提高老年人的独立性。

DESCRIPTION (provided by applicant): This is a competing renewal application for support of the Claude D. Pepper Older Americans Independence Center (OAIC) at the University of Michigan (UM Pepper Center). The specific aims of the UM Pepper Center are: 1) To support research which has a focus on enhancing the independence of older adults by improved understanding of predictors and modulators of the aging phenotype, and its resulting health outcomes. 2) To help maintain and restore the independence of older people by supporting translational research linking basic and clinical research on aging and common health problems of older adults leading to disability. 3) To provide Research Resources Cores (RRCs) that support and assist investigator initiated research projects which can lead to new insights into the basic mechanisms underlying conditions that contribute to the aging phenotype and loss of independence of older adults, and Core Development Projects which develop and test innovative methods to apply to such research projects. 4) Through its Research Career Development Core (RCDC), to strengthen the UM environment for training of future academic leaders in geriatrics and aging who can conduct research on basic mechanisms contributing to the aging phenotype, can develop new methods to enhance translational research, and can carry out clinical trials of promising interventions to enhance independence of older adults. 5) Through its Pilot and Exploratory Studies Core (PESC), to attract UM junior faculty and senior faculty not previously involved in aging research to study problems predisposing to the aging phenotype and to carry out translational research to maintain and enhance independence of older adults. The UM Pepper Center has in place a well established leadership and administrative structure, the key elements of the RCDC and the PESC, and four RRCs, all of which were organized and funded under the auspices of the UM Pepper Center during the previous 14 years. These RRC's include the Human Subjects and Assessment Core (HSAC); the Biomechanies Core; the Methodology, Data Management and Analysis Core (MDMAC); and the Core Facility for Aged Rodents (CFAR). A new Genomic Analysis Core (GAC) is proposed in this application. Six Core Development Projects will strengthen the activities of theses RRCs. The RCDC features three central elements: 1) a competitive program to select promising UM junior faculty for salary support to conduct research relevant to the UM Pepper Center's research focus; 2) a research training program for junior faculty engaged in such research, and 3) a Mentorship Program that permits junior faculty members to work closely with one or more UM senior investigators.