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CORE--ANIMAL

CORE--ANIMAL
核心--动物
批准号：
7618406
负责人：
BYRON C JONES
金额：
$37.9万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7618406
关键词：
AddressAgeAnimal ModelAnimalsAreaAutopsyBehavioralBindingBrainBrain regionBreedingCharacteristicsClinicalCollaborationsComplexComplex Genetic TraitConditionDataDevelopmentDietDisease remissionDopamineDoseExhibitsFerritinFutureGene MutationGenesGeneticGoalsIn complete remissionInbred MouseInbred Strains MiceIndividual DifferencesIntravenousIronMagnetic Resonance ImagingMeasuresMidbrain structureModelingMusNeonatalNuclearPatientsPeripheralPhenotypePliabilityPopulationPre-studyProcessQuantitative GeneticsQuantitative Trait LociRattusRecombinant Inbred StrainRecombinantsRegulationResearchResearch Project GrantsReview CommitteeServicesStaining methodStainsSubstantia nigra structureSucroseSymptomsTimeTissuesWeekanimal tissuebasedaydesigndesireferryl irongenetic analysisiron metabolismprogramsresponserhosuccesstrait

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中文摘要
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英文摘要
The major goal of this proposal is to use genetically defined animals to show how iron content in the brain is related to iron parameters in the periphery. The animal model to be employed in this research consists of a panel of recombinant inbred (RI) mouse strains, to refine the natural traits relating to high- and low-brain iron concentration. The mandate of this Core is to provide animals with phenotypic characteristics relating to brain iron concentration. Aim 1. To provide animals, animal tissue and support service for Projects #3 and #4. Aim 2. To maintain a colony of BXD inbred mice in order to refine the current phenotype or to explore other phenotypic characteristics that are identified in RLS subjects or autopsy material over the ensuing years of the Program Project. Aim 3. To perform quantitative genetic analysis on nigral brain iron content.
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Genetics of epigenetic response to high circulating glucocorticoids and organophosphorus compounds
Genetics of epigenetic response to high circulating glucocorticoids and organophosphorus compounds
Genetics of epigenetic response to high circulating glucocorticoids and organophosphorus compounds
Neural Toxicity of Paraquat is Related to Iron Regulation in the Midbrain
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