CORE--ANIMAL

这项提议的主要目标是使用基因定义的动物来展示大脑中的铁含量与外周组织中的铁参数是如何相关的。这项研究中采用的动物模型由一组重组近交系(RI)小鼠品系组成，以提炼与高和低脑铁浓度相关的自然特征。这个核心的任务是为动物提供与脑铁浓度相关的表型特征。 目标1.为项目3、4提供动物、动物组织及支持服务。 目的2.维持一群BXD近交系小鼠，以完善当前的表型或探索RLS受试者或尸检材料中在接下来的几年中发现的其他表型特征。 目的3.对黑质脑铁含量进行定量遗传分析。

The major goal of this proposal is to use genetically defined animals to show how iron content in the brain is related to iron parameters in the periphery. The animal model to be employed in this research consists of a panel of recombinant inbred (RI) mouse strains, to refine the natural traits relating to high- and low-brain iron concentration. The mandate of this Core is to provide animals with phenotypic characteristics relating to brain iron concentration. Aim 1. To provide animals, animal tissue and support service for Projects #3 and #4. Aim 2. To maintain a colony of BXD inbred mice in order to refine the current phenotype or to explore other phenotypic characteristics that are identified in RLS subjects or autopsy material over the ensuing years of the Program Project. Aim 3. To perform quantitative genetic analysis on nigral brain iron content.