CORE--ANIMAL

核心--动物

• 批准号: 6719148
• 负责人: BYRON C JONES
• 金额: $ 20.39万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6719148
• 关键词: abnormal involuntary movement; animal breeding; biomedical facility; brain; disease /disorder model; genetic screening; genetic strain; genetically modified animals; laboratory mouse; leg; limb movement; model design /development; phenotype; substantia nigra

The major goal of this proposal is to use genetically defined animals to show how iron content in the brain is related to iron parameters in the periphery. The animal model to be employed in this research consists of a panel of recombinant inbred (RI) mouse strains, to refine the natural traits relating to high- and low-brain iron concentration. The mandate of this Core is to provide animals with phenotypic characteristics relating to brain iron concentration. Aim 1. To provide animals, animal tissue and support service for Projects #3 and #4. Aim 2. To maintain a colony of BXD inbred mice in order to refine the current phenotype or to explore other phenotypic characteristics that are identified in RLS subjects or autopsy material over the ensuing years of the Program Project. Aim 3. To perform quantitative genetic analysis on nigral brain iron content.

这项提案的主要目标是使用遗传定义的动物来显示大脑中的铁含量如何与周围的铁参数相关。本研究中采用的动物模型由一组重组近交系（RI）小鼠品系组成，以完善与高和低脑铁浓度相关的自然特征。该核心的任务是为动物提供与脑铁浓度相关的表型特征。 目标1.为项目#3和#4提供动物、动物组织和支持服务。 目标2.维持BXD近交系小鼠群体，以完善当前表型或探索在项目随后几年中在RLS受试者或尸检材料中鉴定的其他表型特征。 目标3.对黑质脑铁含量进行定量遗传分析。