Point Source Ozonation to Minimize Antibiotic Resistance

点源臭氧氧化可最大限度地减少抗生素耐药性

• 批准号: 7622638
• 负责人: Scott Osborn
• 金额: $ 32.78万
• 依托单位: BLUEINGREEN, LLC
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-15 至 2010-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7622638
• 关键词: Address; Antibiotic Resistance; Antibiotics; Arkansas; Capital; Chemicals; Chlorine; Decontamination; Devices; Disinfection; Economics; Ecosystem; Effectiveness; Environment; Excision; Functional disorder; Goals; Human; Marketing; Measures; Methods; Microbe; Mission; National Institute of Environmental Health Sciences; Operative Surgical Procedures; Oxygen; Ozone; Pharmacologic Substance; Phase; Plasmids; Refractory; Research; Residual state; Resistance; Source; System; Technology; Treatment Effectiveness; Universities; aqueous; base; cost; human disease; pathogen; prevent; public health relevance

DESCRIPTION (provided by applicant): In this Phase II project, BlueInGreen, LLC will build a hypersaturated dissolved ozone (HYDOZTM) unit to deploy in a large pilot-scale study at Springdale Wastewater Treatment Facility (SWWTF) in Springdale, Arkansas. Furthermore, BlueInGreen will collaborate with the University of Arkansas to measure the ability of HYDOZ ozonation to remove refractory microbes and stable chemical contaminants from wastewater effluent in both lab-scale and pilot- scale studies. Phase I results demonstrated the increased efficiency and effectiveness of HYDOZ ozone treatment at bench scale compared to conventional ozonation systems. Phase II research will focus on stable contaminants and refractory microbes that are not removed from wastewater using standard chlorine-based disinfection. We will show that the use of the HYDOZ to treat wastewater at centralized wastewater treatment facilities is a viable method economically and technologically to prevent the release of pharmaceutical residuals and resistant microbes to the environment. This project directly addresses the mission of the National Institute of Environmental Health Sciences to reduce the burden of human disease and dysfunction from the environment and will demonstrate both the efficacy and efficiency of HYDOZ ozonation of wastewater effluent. The specific Phase II objectives are: " Objective 1: Compare cost and efficacy of the HYDOZ to standard disinfection/decontamination technology (BlueInGreen). Milestone 1: The capitol and operating cost of HYDOZ systems is superior to chlorine-based disinfection systems, and based on standard effluent quality parameters, the HYDOZ systems are superior to chlorine-based disinfection systems for treatment of wastewater effluent. " Objective 2: Study HYDOZ destruction of a range of chemical contaminants in wastewater effluent (BlueInGreen). Milestone 2: The HYDOZ ozonation systems will cause a minimum 90% reduction in concentration of at least six chemical contaminants from wastewater effluent. " Objective 3: Study HYDOZ destruction of plasmids and refractory microbes in wastewater effluent (University of Arkansas). Milestone 3: The HYDOZ ozonation systems will cause a minimum 90% reduction in concentration of plasmids and refractory microbes from wastewater effluent. PUBLIC HEALTH RELEVANCE: The goal of this project is to use the hypersaturated dissolved ozone (HYDOZTM) system to remove stable chemical/pharmaceutical residuals and refractory microbes from wastewater. Successful reduction of the occurrence of these contaminants in the aqueous environment will reduce long-term impacts on ecosystems and humans, and reduce the spread of antibiotic resistant microbes. The widespread use of this device will significantly contribute to the reduction of antibiotic resistant pathogens in the human ecosystem and help maintain the efficacy of medically important antibiotics.

描述（由申请人提供）：在此第二阶段项目中，BlueInGreen, LLC 将建造一个超饱和溶解臭氧 (HYDOZTM) 装置，用于在阿肯色州斯普林代尔的斯普林代尔废水处理设施 (SWWTF) 进行的大型试点研究中部署。此外，BlueInGreen 将与阿肯色大学合作，在实验室规模和中试规模的研究中测量 HYDOZ 臭氧化去除废水中难降解微生物和稳定化学污染物的能力。第一阶段的结果表明，与传统臭氧化系统相比，HYDOZ 臭氧处理在实验室规模上的效率和有效性有所提高。第二阶段的研究将重点关注使用标准氯消毒无法从废水中去除的稳定污染物和难降解微生物。我们将证明，使用 HYDOZ 在集中废水处理设施处理废水是一种经济上和技术上可行的方法，可以防止药物残留和耐药微生物向环境释放。该项目直接体现了国家环境健康科学研究所的使命，即减少人类疾病负担和环境功能障碍，并将展示 HYDOZ 臭氧化废水处理的功效和效率。第二阶段的具体目标是：“目标 1：比较 HYDOZ 与标准消毒/净化技术 (BlueInGreen) 的成本和功效。里程碑 1：HYDOZ 系统的资本和运营成本优于氯基消毒系统，并且基于标准废水质量参数，HYDOZ 系统在处理废水废水方面优于氯基消毒系统。” 2：研究 HYDOZ 对废水中一系列化学污染物的破坏 (BlueInGreen)。里程碑 2：HYDOZ 臭氧化系统将使废水中至少六种化学污染物的浓度降低至少 90%。目标 3：研究 HYDOZ 对废水中质粒和难降解微生物的破坏（阿肯色大学）。里程碑 3：HYDOZ 臭氧化系统将导致废水中质粒和难降解微生物的浓度至少降低 90%。 公共健康相关性：该项目的目标是使用超饱和溶解臭氧 (HYDOZTM) 系统去除废水中稳定的化学/药物残留物和难降解微生物。成功减少水环境中这些污染物的出现将减少对生态系统和人类的长期影响，并减少抗生素耐药微生物的传播。该设备的广泛使用将极大地有助于减少人类生态系统中的抗生素耐药病原体，并有助于维持医学上重要的抗生素的功效。