Microarray Chips for Rapid Detection of High Affinity Nucleic Acid Sequences.

描述（由申请人提供）：该II期项目旨在进一步推进和商业化基于微阵列的筛选方法，用于发现对蛋白质和细胞靶标具有高亲和力和高特异性的核酸探针。在这些筛选中发现的寡核苷酸可以被工程化为对药物开发、环境传感和POC诊断具有灵敏度和选择性的传感器;这些领域目前由基于抗体的技术主导。在第二阶段，我们计划追求与每个细分市场相关的蛋白质目标，努力简化商业化过程并建立广泛的产品组合。 公共卫生相关性：在第二阶段项目中进一步开发的Combigen筛选过程将创建特异性结合蛋白质靶点的分子探针。这些探针将在环境传感、即时诊断和药物治疗中找到应用。

DESCRIPTION (provided by applicant): This Phase II project aims at further advancing and commercializing a microarray-based screening approach, for discovering nucleic acid probes that have high affinity and high specificity for protein and cellular targets. Oligonucleotides discovered in these screens can be engineered into sensors having exquisite sensitivity and selectivity for drug development, environmental sensing and POC-diagnostics; areas currently dominated by antibody based technologies. In Phase II we plan to pursue protein targets that are relevant to each of these market segments, in an effort streamline the commercialization process and establish a broad product portfolio. PUBLIC HEALTH RELEVANCE: The Combigen screening process being further developed in this phase II project will create molecular probes that specifically bind protein based targets. These probes will find applications in environmental sensing, point-of-care diagnostics and drug therapies.