THE ROLE OF FORMATION OF SOLUBLE OLIGOMERS IN THE GROWTH OF AMYLOID FIBRILS

可溶性低聚物的形成在淀粉样原纤维生长中的作用

• 批准号: 7597963
• 负责人: SEBASTIAN DONIACH
• 金额: $ 0.02万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7597963
• 关键词: Alzheimer' s Disease; Amino Acid Sequence; Amyloid Fibrils; Computer Retrieval of Information on Scientific Projects Database; Deposition; Disease; Funding; Generic Drugs; Grant; Growth; Health; Human; Institution; Mutation; Numbers; Parkinson Disease; Peptide Sequence Determination; Phenotype; Positioning Attribute; Range; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; Yeasts; amyloid formation; interest; polypeptide

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Formation of amyloid fibrilar deposits occurs in a number of diseases and also appears to occur as a natural cause of certain epi-genetic changes of phenotype in yeast. Evidence that formation of amyloid seems to be generic to polypeptide chains suggests that the ability to identify specific positions in a protein sequence involved in oligomerization will allow a closer analysis of the underlying mechanism for amyloid formation in general, which is of interest in a large range of contexts, including major impacts on human health such as Alzheimer's and Parkinson's diseases.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 淀粉样纤维沉积的形成发生在许多疾病中，也似乎是酵母某些表型表型表观遗传变化的自然原因。淀粉样蛋白的形成似乎是多肽链的通用证据表明，识别参与寡聚的蛋白质序列中特定位置的能力将使人们能够更深入地分析淀粉样蛋白形成的潜在机制，这在广泛的背景下是有意义的，包括对人类健康的重大影响，如阿尔茨海默氏症和帕金森氏病。