A MOLECULAR FOUNDATION FOR THE TREATMENT OF ARSENIC POISONING IN BANGLADESH

孟加拉国治疗砷中毒的分子基础

• 批准号: 7598146
• 负责人: GRAHAM N GEORGE
• 金额: $ 0.14万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7598146
• 关键词: Affect; Area; Arsenic; Arsenic Poisoning; Bangladesh; Chronic; Computer Retrieval of Information on Scientific Projects Database; Foundations; Funding; Grant; Institution; Molecular; Poisoning; Research; Research Personnel; Resources; Roentgen Rays; Source; Spectrum Analysis; Toxic effect; United States National Institutes of Health; Work; absorption; selenium deficiency

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In what has been called the world¿s worst mass poisoning, between 35 and 70 million people are affected by chronic low-level arsenic poisoning in Bangladesh and surrounding areas. We have previously suggested that this poisoning is not directly due to the toxic effects of arsenic, but is instead primarily due to arsenic-induced selenium deficiency. We plan to build on our earlier work to provide a molecular foundation for the treatment of chronic low-level arsenic poisoning in Bangladesh and other affected areas. X-ray absorption spectroscopy (XAS) holds the key to these discoveries.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在被称为世界上最严重的S大规模中毒事件中，孟加拉国及周边地区有3500万至7000万人受到慢性低水平砷中毒的影响。我们以前曾认为，这种中毒不是直接由于砷的毒性作用，而是主要由于砷引起的硒缺乏。我们计划在早期工作的基础上，为孟加拉国和其他受影响地区慢性低水平砷中毒的治疗提供分子基础。X射线吸收光谱(XAS)是这些发现的关键。