COLLECTION OF PROTEIN CRYSTALLOGRAPHIC DATA

蛋白质晶体学数据的收集

• 批准号: 7598155
• 负责人: GYORGY SNELL
• 金额: $ 0.02万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7598155
• 关键词: Collection; Computer Retrieval of Information on Scientific Projects Database; Data; Drug Design; Equipment; Freezing; Funding; Grant; Institution; Phase; Procedures; Proteins; Proteomics; Research; Research Personnel; Resources; Roentgen Rays; Site; Source; Standards of Weights and Measures; Structure; Time; United States National Institutes of Health; X ray diffraction analysis; X-Ray Diffraction; base; beamline; microbial; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Syrrx is a structural proteomics company based in San Diego doing structure-based drug design. Several targets of microbial proteins have been crystallized at Syrrx, characterized with monochromatic X-rays. In order to phase these we have grown and crystallized these proteins with Se-Met substitution and are seeking MAD beam time. We will be collecting protein crystal X-ray diffraction data at beamline 9-2. We will be using standard beamline operating procedures and equipment. All crystals are being brought to SSRL pre-frozen and will be removed from the site at the end of the experiment.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 Syrx是一家总部位于圣地亚哥的结构蛋白质组公司，从事基于结构的药物设计。几个微生物蛋白质的目标已经在Syrrx结晶，并用单色X射线进行了表征。为了使这些蛋白质相态，我们已经用Se-Met替代生长和结晶了这些蛋白质，并正在寻找疯狂的束流时间。我们将在光束线9-2收集蛋白质晶体X射线衍射数据。我们将使用标准的光束线操作程序和设备。所有的晶体都被带到SSRL预冻，并将在实验结束时从现场移除。