STRUCTURE AIDED DRUG DISCOVERY RESEARCH OF ANTI-MICROBIAL TARGETS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。Syrrx是一家位于圣地亚哥的结构蛋白质组学公司，从事基于结构的药物设计。在Syrrx，几种专有的微生物蛋白质目标已经结晶，其特征在于单色X射线。为了定相这些，我们已经用Se-Met取代生长和结晶这些蛋白质，并且正在寻求MAD束时间。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Syrrx is a structural proteomics company based in San Diego doing structure-based drug design. Several proprietary targets of microbial proteins have been crystallized at Syrrx, characterized with monochromatic X-rays. In order to phase these we have grown and crystallized these proteins with Se-Met substitution and are seeking MAD beam time.