STRUCTURE & MECHANISM OF HYDROLYTIC ANTIBODIES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们正在研究一种独特的催化抗体家族的结构和机制，以努力建立规则，允许产生更活跃的催化抗体。利用各种化学、生化和分子生物学技术，我们正在以结构引导的方式对我们的催化抗体进行工程改进。我们的目标是监测在设计这些催化改进过程中涉及的结构-功能关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are studying the structure and mechanisms of a unique family of catalytic antibodies in an effort to establish rules that will permit more active catalytic antibodies to be generated. Using a variety of chemical, biochemical and molecular biology techniques, we are engineering improvements into our catalytic antibodies in a structure-guided way. Our goal is to monitor the structure-function relationships involved in engineering these catalytic improvements.