STRUCTURE & MECHANISM OF HYDROLYTIC ANTIBODIES

结构

• 批准号: 6308885
• 负责人: THOMAS Sterling SCANLAN
• 金额: $ 0.99万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6308885
• 关键词: biological products; biomaterials; biomedical resource; biotechnology; spectrometry; structural biology

We are studying the structure and mechanisms of a unique family of catalytic antibodies in an effort to establish rules that will permit more active catalytic antibodies to be generated. Using a variety of chemical, biochemical and molecular biology techniques, we are engineering improvements into our catalytic antibodies in a structure-guided way. Our goal is to monitor the structure-function relationships involved in engineering these catalytic improvements.

我们正在研究一个独特的家族的结构和机制 催化抗体，以努力建立规则，以允许 将产生更活跃的催化抗体。使用各种不同的 化学、生化和分子生物学技术，我们是 对我们的催化抗体进行了工程改进 结构导向的方式。我们的目标是监测结构-功能 在设计这些催化改进的过程中涉及的关系。