STRUCTURE & MECHANISM OF HYDROLYTIC ANTIBODIES

结构

• 批准号: 7369025
• 负责人: THOMAS Sterling SCANLAN
• 金额: $ 0.77万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7369025
• 关键词: STRUCTURE; MECHANISM; HYDROLYTIC; ANTIBODIES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are studying the structure and mechanisms of a unique family of catalytic antibodies in an effort to establish rules that will permit more active catalytic antibodies to be generated. Using a variety of chemical, biochemical and molecular biology techniques, we are engineering improvements into our catalytic antibodies in a structure-guided way. Our goal is to monitor the structure-function relationships involved in engineering these catalytic improvements. 339S

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。我们正在研究一个独特的催化抗体家族的结构和机制，以努力建立允许产生更多活性催化抗体的规则。利用各种化学、生物化学和分子生物学技术，我们正在以结构引导的方式改进我们的催化抗体。我们的目标是监测这些催化改进工程中涉及的结构-功能关系。 339S