CENTROSOME STRUCTURE

中心体结构

• 批准号: 7598366
• 负责人: ROBERT E PALAZZO
• 金额: $ 2.29万
• 依托单位: WADSWORTH CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7598366
• 关键词: Centrioles; Centrosome; Computer Retrieval of Information on Scientific Projects Database; Developmental Cell Biology; Developmental Process; Fertility; Funding; Grant; Institution; Maintenance; Microtubules; Mitosis; Organelles; Phase; Process; Research; Research Personnel; Resources; Source; Structure; United States National Institutes of Health; base; interest; reconstruction; tumor progression

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The project involves cryo-TEM analysis and reconstruction of isolated centrosomes: analysis of steps in the process of centriole assembly, determination of the structural basis of microtubule nucleation, understanding the structural phases of centrosome assembly, and analysis of the core structure of the centrosome (?centromatrix?), which is currently undefined. Comprehensive analysis of this type on any centrosome has not been done. The centrosome is one of roughly twelve cellular organelles, is required for maintenance of cytoplasmic organization, and is involved in mitosis. Also, centrosome function is critical in fertility and developmental processes. The problem of the centrosome is one of the long standing problems in cell and developmental biology. Centrosome aberrations may be involved in cancer progression. Motile phenomena are often dependent on centrosome function. We believe it is a timely project with a potential high profile given current interest in the subject. This project has not yet started.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目涉及冷冻TEM分析和重建孤立的中心体：分析的步骤，在中心粒组装过程中，微管成核的结构基础的确定，了解中心体组装的结构阶段，并分析中心体的核心结构（？centromatrix？），目前尚未定义。尚未对任何中心体上的这种类型进行全面分析。中心体是大约12个细胞器之一，是维持细胞质组织所必需的，并参与有丝分裂。此外，中心体功能在生育和发育过程中至关重要。中心体问题是细胞和发育生物学中长期存在的问题之一。中心体畸变可能参与癌症进展。 运动现象往往依赖于中心体的功能。我们认为，鉴于目前对该主题的兴趣，这是一个及时的项目，具有潜在的高知名度。 这个项目还没有开始。