SKELETONIZATION OF CRYO-EM DENSITY MAPS

冷冻电镜密度图的骨架化

• 批准号: 7598616
• 负责人: MARC L BAKER
• 金额: $ 1.63万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7598616
• 关键词: Address; Computer Retrieval of Information on Scientific Projects Database; Detection; Elements; Funding; Grant; Institution; Maps; Measures; Research; Research Personnel; Resolution; Resources; Source; Structure; United States National Institutes of Health; alpha helix; beta pleated sheet; density; novel; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We aim to develop a novel framework for the simultaneous identification of both alpha-helices and beta-sheets in intermediate resolution (10-5 ¿) density maps. In addition to the detection of secondary structure elements, both confidence measures and topology are addressed, resulting in a simple yet comprehensive tool for analyzing, visualizing and annotating density maps.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们的目标是开发一种新的框架，同时识别α-螺旋和β-片层的中间分辨率（10-5 <$）密度图。除了二级结构元素的检测，置信度和拓扑结构都得到了解决，从而产生了一个简单而全面的工具，用于分析，可视化和注释密度图。