SKELETONIZATION OF CRYO-EM DENSITY MAPS

冷冻电镜密度图的骨架化

• 批准号: 7357808
• 负责人: MARC L BAKER
• 金额: $ 1.51万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7357808
• 关键词: SKELETONIZATION; CRYO; EM; DENSITY; MAPS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We aim to develop a novel framework for the simultaneous identification of both alpha-helices and beta-sheets in intermediate resolution (10-5 ¿) density maps. In addition to the detection of secondary structure elements, both confidence measures and topology are addressed, resulting in a simple yet comprehensive tool for analyzing, visualizing and annotating density maps.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。我们的目标是开发一种新的框架，用于在中等分辨率（10-5¿）密度图中同时识别α -螺旋和β -片。除了二级结构元素的检测外，还解决了置信度措施和拓扑结构，从而形成了一个简单而全面的工具，用于分析，可视化和注释密度图。