SKELETONIZATION OF CRYO-EM DENSITY MAPS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们的目标是开发一种新的框架，同时识别α-螺旋和β-片层的中间分辨率（10-5 <$）密度图。除了二级结构元素的检测，置信度和拓扑结构都得到了解决，从而产生了一个简单而全面的工具，用于分析，可视化和注释密度图。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We aim to develop a novel framework for the simultaneous identification of both alpha-helices and beta-sheets in intermediate resolution (10-5 ¿) density maps. In addition to the detection of secondary structure elements, both confidence measures and topology are addressed, resulting in a simple yet comprehensive tool for analyzing, visualizing and annotating density maps.