STRUCTURAL DYNAMICS OF VIRUSES

病毒的结构动力学

• 批准号: 7601247
• 负责人: PETER FREDDOLINO
• 金额: $ 6.19万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601247
• 关键词: Capsid; Capsid Proteins; Complement; Computer Retrieval of Information on Scientific Projects Database; Disease; Funding; Genome; Grant; Individual; Infection; Institution; Movement; Numbers; Organism; Property; Research; Research Personnel; Resolution; Resources; Source; Staging; Structure; Time; United States National Institutes of Health; Viral; Viral Proteins; Virion; Virus; Virus Diseases; research study; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Viruses are parasitic organisms responsible for many diseases. A virus consists of a genome enclosed in a protein coat (capsid), often with a few other accessory molecules. Viral infection depends on the ability of a virion to maintain its stability, disassemble, or assemble depending on the infection stage; these steps are determined by interactions between the viral components, as well as by external factors. Thus, studying the dynamics of viral components is crucial for elucidation of the mechanisms of viral infections. Although a large number of viruses have been structurally resolved (see, e.g., [1]), a static structure does not reveal dynamical properties; also, the spatial and temporal resolution of real-time experiments (e.g. [2, 3]) is usually much lower than that required to distinguish the movements of individual viral proteins. In this situation, MD studies are perfectly suited to complement experiments, as MD simulations are now capable of describing the dynamics of complete viruses at atomic resolution [4] (http://www.ks.uiuc.edu/Research/STMV).

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 病毒是引起许多疾病的寄生生物。 病毒由包在蛋白质外壳（衣壳）中的基因组组成，通常还有一些其他辅助分子。 病毒感染取决于病毒体维持其稳定性、分解或组装的能力，这取决于感染阶段;这些步骤由病毒组分之间的相互作用以及外部因素决定。 因此，研究病毒组分的动力学对于阐明病毒感染的机制至关重要。 尽管大量病毒已经在结构上被解析（参见，例如，[1])静态结构不能揭示动态特性;此外，实时实验的空间和时间分辨率（例如[2，3]）通常远低于区分单个病毒蛋白质运动所需的分辨率。 在这种情况下，MD研究非常适合补充实验，因为MD模拟现在能够以原子分辨率描述完整病毒的动力学[4]（http：//www.ks.uiuc.edu/Research/STMV）。