LIPID-PROTEIN INTERACTIONS INVESTIGATED BY FLUORESCENCE MICROSCOPY

通过荧光显微镜研究脂质-蛋白质相互作用

• 批准号: 7600946
• 负责人: ROLAND HA WINTER
• 金额: $ 1.28万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7600946
• 关键词: Buffers; Computer Retrieval of Information on Scientific Projects Database; Detection; Fluorescence Microscopy; Funding; Grant; Growth; Institution; Label; Lipids; Membrane; Proteins; Research; Research Personnel; Resources; Source; System; Time; Title; United States National Institutes of Health; base

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. FULL TITLE: Lipid-protein interactions investigated by fluorescence microscopy (with focus on amyloidogenic proteins and anionic GUVs) growth of GUVs based on anionic lipid mixtures in different buffer systems; interactions of Nh-RhDHPE-labeled GUVs and CF-labeled amyloidogenic proteins are observed by 2-channel detection; observation of perturbations of membrane integrity upon interaction; time-dependent and concentration-dependent studies

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 全标题：通过荧光显微镜研究脂质-蛋白质相互作用（重点是淀粉样蛋白和阴离子GUV） 基于阴离子脂质混合物的GUV在不同缓冲系统中的生长;通过2通道检测观察Nh-RhDHPE标记的GUV和CF标记的淀粉样蛋白的相互作用;观察相互作用后膜完整性的扰动;时间依赖性和浓度依赖性研究