129XE POLARIZATION OPTIMIZATION AND IMAGING METHOD DEVELOPMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本项目的目标是改善129Xe的极化和体积，并证明提高了 图像质量-开发新的成像和光谱分析范例，这将是迄今为止无法获得的 有关肺功能的信息 改善图像的演示是显示偏振增强的实用性的关键。 方法将包括129Xe线圈的开发、调谐和模体测试；健康的动物通风 PR和GRASS序列成像；肺膜波谱序列的开发。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this project are to - improve the polarization and volume of 129Xe and to demonstrate increased image quality - develop novel imaging and spectroscopy paradigms, which will give heretofore unobtainable information about lung function Demonstration of improved images is critical to show the utility of the polarization enhancement. Methods will include 129Xe coil development, tuning and testing with phantoms; healthy animal ventilation imaging with PR and GRASS sequences; development of pulmonary membrane spectroscopy sequences.