EVALUATION OF NOVEL SPIO CONTRAST AGENTS IN A MODEL OF MULTIPLE SCLEROSIS

新型 SPIO 造影剂在多发性硬化症模型中的评价

• 批准号: 7601159
• 负责人: DAN M MEYER
• 金额: $ 0.5万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601159
• 关键词: Acute; Brain; Clinical; Computer Retrieval of Information on Scientific Projects Database; Contrast Media; Encephalomyelitis; Evaluation; Experimental Autoimmune Encephalomyelitis; Funding; Grant; Institution; Life; Modeling; Multiple Sclerosis; New Agents; Noise; Pilot Projects; Rattus; Research; Research Personnel; Resolution; Resources; Scanning; Source; Spinal Cord Lesions; Tissue Sample; United States National Institutes of Health; interest; iron oxide; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are developing proprietary SPIO (superparamagnetic iron oxide) contrast agents and are currently evaluating them in an rat model of MS (acute experimental autoimmune encephalomyelitis, EAE). Because at our facility we are presently limited to scanning using a 1.5 T clinical scanner, we interested in exploring whether the higher field and resolution that your facility is capable of providing could significantly aid in our evalution of these new agents. We propose a pilot study to quantify the contrast to noise that can be observed in the brain/upper spinal cord lesions that are present in the EAE model. This could be done either on tissue samples (or carcasses) that we prepare and then send to you, or it could be done on live rats at your facility.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们正在开发专有的SPIO（超帕磁铁氧化铁）对比剂，目前正在MS（急性实验性自身免疫性脑脊髓炎）中对其进行评估。 因为在我们的设施中，我们目前仅限于使用1.5 T临床扫描仪进行扫描，因此我们有兴趣探索您的设施能够提供的较高领域和解决方案是否可以大大帮助我们评估这些新代理。 我们提出了一项试点研究，以量化与EAE模型中存在的大脑/上脊髓病变中可以观察到的噪声的对比。 这可以在我们准备的组织样品（或尸体）上进行，然后发送给您，也可以在您的设施的活老鼠上完成。