CELLULAR LOCALISATION OF THE TRANSCRIPTIONAL REGULATORS E12 AND E47

转录调节因子 E12 和 E47 的细胞定位

• 批准号: 7601075
• 负责人: CORNELIS MURRE
• 金额: $ 2.17万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601075
• 关键词: B-Cell Development; B-Lymphocytes; Computer Retrieval of Information on Scientific Projects Database; Funding; Gene Expression; Grant; Immunoglobulin Gene Rearrangement; Institution; Label; Research; Research Personnel; Resources; Source; Staging; TCF3 gene; United States National Institutes of Health; helix-loop-helix protein E12

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The E2A proteins E12 and E47 are expressed throughout B-cell development to activate B-cell specific gene expression and immunoglobulin gene rearrangement. Here we propose to examine the cellular localization of E12 and E47 during distinct stages of B-cell development, specifically we would examine localization utilizing tetracysteine-biarsenical labeling.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 E2 A蛋白E12和E47在整个B细胞发育过程中表达，以激活B细胞特异性基因表达和免疫球蛋白基因重排。在这里，我们建议检查E12和E47在B细胞发育的不同阶段的细胞定位，特别是我们将检查定位利用四环素双砷标记。