MITOCHONDRIAL BIOENERGETICS IN NEURONS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our goal is to identify promising gaps in current knowledge regarding the roles for mitochondria in providing energy for use in signal transduction, protein synthesis, neuronal plasticity and learning. Local regulation of protein synthesis at dendritic spines for synaptic plasticity is under intensive investigation by many laboratories. Yet, we noticed that local regulation of mitochondrial ATP production and protein synthesis was almost totally ignored in this context. Our Arrowsmith searches suggest that mitochondrial protein synthesis might be involved in regulating longterm potentiation, dendritic spine development or synaptic plasticity, particularly in late or sustained phases of consolidation and growth.