T-BOX CARDIAC PHENOTYPE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 T-box（Tbx）转录因子在物种间高度保守，在多种组织类型中表达，并且是多种器官和组织发育所需的。T-box基因调节模式和细胞命运、细胞存活和/或增殖，并且也具有很大的临床相关性。Tbx 18是一种T-box转录因子，已被描述为从心外膜器官的最早阶段表达。为了研究Tbx 18对心脏发育的作用及其与人类先天性心脏病的临床相关性，我已经产生了Tbx 18的无效等位基因小鼠。我们想做一些TEM分析，以确定Tbx 18基因敲除小鼠的心脏缺陷，通过比较它们与野生型同窝出生。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. T-box (Tbx) transcription factors are highly conserved across species, expressed in a wide variety of tissue types, and are required for development of diverse organs and tissues. T-box genes regulate patterning and cell fate, cell survival and/or proliferation, and are also of great clinical relevance. Tbx18 is a T-box transcription factor that has been described as being expressed from earliest stages in the proepicardial organ. To study the role of Tbx18 for heart development and its clinical relevance for human congenital heart disease, I have generated a null allele mouse of Tbx18. We would like to do some TEM analysis to determine cardiac defects of Tbx18 null mouse, by comparing them with wild type littermates.