FOLLOW-UP STUDY OF NEUROLOGICAL RISKS IN AMATEUR BOXING

业余拳击神经风险的后续研究

• 批准号: 3412295
• 负责人: WALTER F STEWART
• 金额: $ 37.2万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-01 至 1991-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3412295
• 关键词: brain disorder diagnosis; brain electrical activity; chronic brain damage; computer assisted diagnosis; electrophysiology; epidemiology; head /neck injury; human subject; interview; longitudinal human study; neurologic manifestations; neuropsychological tests; neuropsychology; psychological tests; sports injury

The possibility of long term cerebral damage from the blows that occur in boxing has been a source of considerable controversy for years and may be relevant to the broader issues of head injuries. In many ways, the injuries that occur in amateur boxing, a sport vastly different from professional boxing, are more analogous to those that occur in other sports and accidents. Therefore, a study of whether cerebral damage occurs in amateur boxing would have both specific and broad epidemiologic and medical implications. We have begun and will shortly complete the first phase of a study of 500 amateur boxers designed to answer the question of whether selected neuropsychologic, neurologic, or neurophysiologic changes which occur after a 2-year interval are associated with varying degrees of exposure ranging from essentially none to repeated subconcussive and in some cases, concussive blows. This study is unique in that boxers are identified before any apparent signs of impairment, it is prospective, and involves a representative sample of 500 subjects. In addition, a low dose internal control is used. Our preliminary studies have shown that boxers appear to have enough unique characteristics that other plausible control populations are probably not appropriate. This study design was developed in concert with an external advisory committee comprised of neuropsychologists, an epidemiologist, neurologist, neurosurgeon, biostatistican, boxing coach, and other authorities. This proposal is to request funds for the follow-up measures (after a two year interval) on these same boxers. In the soon to be completed baseline study neuropsychologic, electrophysiologic, and neurologic measures are made in a 4-hour test session. All tests are completed in a mobile clinic. Urine samples are collected to test for recent substance use. A detailed boxing history is obtained from the boxer and coach. The proposed follow-up measures will be made using the baseline study protocol. Follow-up measures are proposed after a 2-year interval, as a compromise between a desire to maintain close contact with subjects and a meaningful interval long enough to observe changes. Interim contact is being maintained with subjects to assure a high follow-up rate in the event that prospective measures are to be made.

长期脑损伤的可能性来自于 拳击中发生的事情一直是一个相当大的争议来源 这可能与头部受伤这一更广泛的问题有关。 在许多方面，业余拳击运动中发生的伤害 与职业拳击截然不同，更类似于 那些发生在其他运动和事故中的。因此，一项研究 在业余拳击中是否会出现脑损伤 既具体又广泛的流行病学和医学影响。 我们已经开始并将很快完成第一阶段的研究 500名业余拳击手，旨在回答这样一个问题 选定的神经心理学、神经学或神经生理学 间隔2年后发生的更改与 暴露程度不同，从基本上没有到 反复的亚震荡打击，在某些情况下，脑震荡打击。这 研究的独特之处在于，拳击手在任何明显的 损害的迹象，它是预期的，并涉及 具有代表性的样本为500人。此外，一个低剂量的 使用了内部控制。我们的初步研究表明 拳击手似乎有足够的独特特征比其他人 看似合理的控制人口可能并不合适。这 研究设计是与外部咨询一起开发的 委员会由神经心理学家、流行病学家、 神经科医生、神经外科医生、生物统计学家、拳击教练等 当局。 这项建议是为后续措施(之后)申请资金 两年的时间间隔)这些相同的拳击手。在不久的将来 完成神经心理学、电生理学、 神经学测量是在4小时的测试过程中进行的。全 测试在一家流动诊所完成。尿样是 收集来测试最近的药物使用情况。详细的拳击 历史是从拳击手和教练那里获得的。建议数 将利用基线研究制定后续措施 协议。两年后提出后续措施 间隔，作为维持亲密关系的愿望之间的妥协 与受试者的接触和足够长的有意义的间隔 观察变化。临时联系正在与 受试者确保在发生以下情况时有较高的随访率 将采取前瞻性的措施。