AN ADAPTIVE BAYESIAN APPROACH TO JOINTLY MODELING RESPONSE AND TOXICITY IN PHAS
AN ADAPTIVE BAYESIAN APPROACH TO JOINTLY MODELING RESPONSE AND TOXICITY IN PHAS
批准号:
7601385
负责人:
ROGER S. DAY
金额:
$0.03万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-08-01 至 2008-07-31
关键词:
AttentionBayesian MethodBiologicalComputer Retrieval of Information on Scientific Projects DatabaseComputer SimulationDataDecision TheoryDoseEventFundingGrantIndividualInstitutionMalignant NeoplasmsModelingNormal Statistical DistributionOutcomePatientsPhasePhase I Clinical TrialsPopulationProbabilityResearchResearch PersonnelResourcesSourceToxic effectUnited States National Institutes of Healthbasedesignresponse
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
We present a new adaptive Bayesian method for dose-finding in phase I clinical trials based on both response and
toxicity under the assumption that the thresholds of response and toxicity jointly follow a bivariate log-normal
distribution. Responses are rare in cancer trials. But biological responses may be common, and may help decide
how aggressive a phase I escalation should be. In an ideal decision theory framework, the choice of dose for each
successive patient would incorporate what is best for the patient, together with the value of the information to be
obtained for the trial. However, to evaluate the latter explicitly would be computationally extremely difficult. For
simplicity, we restrict attention to the probability of each outcome for the next patient only. The model assumes that
response and toxicity events happen depending on the respective dose thresholds for the individual, and provides a
framework for incorporating prior information about the population threshold distribution, as well as accumulated
data. The next dose can be assigned to maximize expected utility. A simple utility function places positive utility
only on the co-occurrence of response and non-toxicity. Computer simulation results show that the proposed design
reliably chooses the preferred dose under different scenarios and different priors.
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科研奖励(0)
会议论文
MARKOV PROCESSES AND CLINICAL TRIAL DESIGN
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批准号:8364221
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项目类别:
-
资助金额:$0.11万
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财政年份:2011
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负责人:ROGER S. DAY
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依托单位:
MARKOV PROCESSES AND CLINICAL TRIAL DESIGN
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批准号:8171795
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项目类别:
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资助金额:$0.11万
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财政年份:2010
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负责人:ROGER S. DAY
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依托单位:
MARKOV PROCESSES AND CLINICAL TRIAL DESIGN
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批准号:7956320
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项目类别:
-
资助金额:$0.08万
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财政年份:2009
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负责人:ROGER S. DAY
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依托单位:
Core--Biostatistics
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批准号:6664456
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项目类别:
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资助金额:$25.04万
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财政年份:2002
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负责人:ROGER S. DAY
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依托单位:
CORE--BIOSTATISTICS/INFORMATICS
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批准号:6659256
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项目类别:
-
资助金额:$16.24万
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财政年份:2002
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负责人:ROGER S. DAY
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依托单位:
Core--Biostatistics
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批准号:6503453
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项目类别:
-
资助金额:$25.04万
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财政年份:2001
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负责人:ROGER S. DAY
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依托单位:
CORE--BIOSTATISTICS/INFORMATICS
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批准号:6480428
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项目类别:
-
资助金额:$15.94万
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财政年份:2001
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负责人:ROGER S. DAY
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依托单位:
CORE--BIOSTATISTICS/INFORMATICS
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批准号:6611150
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项目类别:
-
资助金额:$16.24万
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财政年份:2001
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负责人:ROGER S. DAY
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依托单位:
CORE--BIOSTATISTICS/INFORMATICS
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批准号:6493612
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项目类别:
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资助金额:$16.24万
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财政年份:2001
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负责人:ROGER S. DAY
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依托单位:
Core--Biostatistics
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批准号:6217389
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项目类别:
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资助金额:$0.0万
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财政年份:1999
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负责人:ROGER S. DAY
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依托单位:
Core--Biostatistics
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批准号:6295942
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项目类别:
-
资助金额:$0.0万
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财政年份:1999
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负责人:ROGER S. DAY
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依托单位:
CORE--BIOSTATISTICS/INFORMATICS
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批准号:6144263
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项目类别:
-
资助金额:$0.0万
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财政年份:1999
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负责人:ROGER S. DAY
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依托单位:
EDUCATIONAL RESOURCE FOR TUMOR HETEROGENEITY
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批准号:6534603
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项目类别:
-
资助金额:$25.95万
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财政年份:1995
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负责人:ROGER S. DAY
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依托单位:
EDUCATIONAL RESOURCE FOR TUMOR HETEROGENEITY
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批准号:2105475
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项目类别:
-
资助金额:$23.3万
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财政年份:1995
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负责人:ROGER S. DAY
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依托单位:
EDUCATIONAL RESOURCE FOR TUMOR HETEROGENEITY
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批准号:2748757
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项目类别:
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资助金额:$20.72万
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财政年份:1995
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负责人:ROGER S. DAY
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依托单位:
EDUCATIONAL RESOURCE FOR TUMOR HETEROGENEITY
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批准号:6649296
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项目类别:
-
资助金额:$26.73万
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财政年份:1995
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负责人:ROGER S. DAY
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依托单位:
EDUCATIONAL RESOURCE FOR TUMOR HETEROGENEITY
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批准号:6193555
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项目类别:
-
资助金额:$24.46万
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财政年份:1995
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负责人:ROGER S. DAY
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依托单位:
EDUCATIONAL RESOURCE FOR TUMOR HETEROGENEITY
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批准号:2105477
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项目类别:
-
资助金额:$19.82万
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财政年份:1995
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负责人:ROGER S. DAY
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依托单位:
EDUCATIONAL RESOURCE FOR TUMOR HETEROGENEITY
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批准号:2458114
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项目类别:
-
资助金额:$19.99万
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财政年份:1995
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负责人:ROGER S. DAY
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依托单位:
EDUCATIONAL RESOURCE FOR TUMOR HETEROGENEITY
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批准号:6402507
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项目类别:
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资助金额:$25.19万
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财政年份:1995
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负责人:ROGER S. DAY
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依托单位:
海外基金