MAXWELL'S EQUATIONS MODELING OF BIOLOGICAL TISSUE OPTICS FOR IMPROVING EARLY ST

用于改善早期 ST 的生物组织光学麦克斯韦方程模型

• 批准号: 7601309
• 负责人: ALLEN TAFLOVE
• 金额: $ 0.03万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601309
• 关键词: Address; Algorithms; Biological; Biological Models; Cancer Detection; Clinical; Colon; Colon Carcinoma; Computer Retrieval of Information on Scientific Projects Database; Computing Methodologies; Detection; Development; Diffusion; Epithelial; Equation; Funding; Genus Cola; Grant; Institution; Investigation; Lead; Methods; Modeling; Optics; Photons; Physics; Precancerous Conditions; Procedures; Rate; Research; Research Personnel; Resolution; Resources; Sampling; Source; Staging; Techniques; Time; Tissues; United States National Institutes of Health; abstracting; base; improved; instrument; nanometer; vector

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Keywords: Maxwell's equations, tissue optics, coherent backscattering, random media, early stage cancer detection, epithelial tissues, colon cancer Abstract: This project addresses the development of computational methodologies to model and analyze optical propagation within, and scattering by, biological tissues. The numerical investigation is based on two related algorithms: (1) the finite-difference time-domain (FDTD) method, which enables solving the full-vector Maxwells equations for optical interactions with biological tissues with nanometer spatial resolution; and (2) the pseudospectral time-domain (PSTD) technique, a recent technical advance of the FDTD method which allows spatial sampling approaching the Nyquist rate, and therefore enables modeling optical-tissue interactions at macroscopic scales. Our specific modeling efforts are aimed at understanding the physics of the recently observed phenomenon of low-coherence optical backscattering, which has significant promise for improving early-stage cancer detection in epithelial tissues, especially the colon. At present, approximate models involving photon diffusion and transport provide an inadequate physics basis because of their inability to treat near and evanescent fields and polarization. Establishment of a rigorous physical understanding of low-coherence optical backscattering by solving the underlying full-vector Maxwells equations could lead to the development of optimized clinical instruments and procedures capable of accelerated detection of precancerous conditions in epithelial tissues.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 保留字： 麦克斯韦方程组，组织光学，相干后向散射，随机介质，早期癌症检测，上皮组织，结肠癌 摘要： 这个项目致力于发展计算方法来模拟和分析生物组织内的光传播和散射。数值研究基于两种相关的算法：（1）时域有限差分（FDTD）方法，它能够以纳米空间分辨率求解全矢量Maxwells方程;以及（2）伪谱时域（PSTD）技术，FDTD方法的最新技术进步，其允许接近奈奎斯特速率的空间采样，因此能够在宏观尺度上模拟光学-组织相互作用。我们的具体建模工作旨在了解最近观察到的低相干光学后向散射现象的物理学，这对于改善上皮组织，特别是结肠中的早期癌症检测具有重要的前景。目前，涉及光子扩散和输运的近似模型由于不能处理近场和倏逝场以及偏振态，提供的物理基础不足。建立一个严格的物理理解低相干光学后向散射通过解决潜在的全矢量麦克斯韦方程可能会导致优化的临床仪器和程序的发展，能够加速检测上皮组织中的癌前病变。