CALCIUM-MEDIATED EXOCYTOSIS OF NEUROTRANSMITTER DURING SYNAPTIC TRANSMISSION
突触传递过程中钙介导的神经递质胞吐作用
基本信息
- 批准号:7601662
- 负责人:
- 金额:$ 0.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-05-01 至 2008-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressCalciumCell membraneChemical SynapseChromosome PairingClassComputer Retrieval of Information on Scientific Projects DatabaseCytoplasmDependenceDimensionsElectronsExocytosisFundingGoalsGrantHair CellsInstitutionLeadLocationMeasuresMediatingModelingNeurotransmittersNumbersOrganellesPhysiologicalResearchResearch PersonnelResourcesSourceSynapsesSynaptic TransmissionSynaptic VesiclesTestingUnited States National Institutes of HealthVesicleWorkbody mapmathematical modelpresynapticsynaptic function
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The long-term goal of these studies is to understand the presynaptic mechanisms of transmitter release at fast chemical synapses. Our specific objective is to reconstruct in three dimensions the ultrastructure of the hair cell afferent synapse in order to test several aspects of our working model of this synapse's function. The hair cell afferent synapse is a ribbon-class synapse, characterized by an electron dense organelle of unknown function, the synaptic body, which appears to hover in the cytoplasm a vesicle's breadth above the active zone. Clear-core vesicles surround the synaptic body, but are also found in the cytoplasm, and associated with the plasma membrane at the active zone. What is the function of the synaptic body, and what is the functional significance of these various pools of vesicles? We will address these issues by determining the precise geometry of the active zone and synaptic body, and map the number and location of synaptic vesicles. By testing the activity-dependence of these measures, we will be able to integrate ultrastructure with ongoing physiological and mathematical modeling studies to build a more detailed understanding of the steps that lead to transmitter exocytosis.
这个子项目是众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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WILLIAM M ROBERTS其他文献
WILLIAM M ROBERTS的其他文献
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{{ truncateString('WILLIAM M ROBERTS', 18)}}的其他基金
CALCIUM-MEDIATED EXOCYTOSIS OF NEUROTRANSMITTER DURING SYNAPTIC TRANSMISSION
突触传递过程中钙介导的神经递质胞吐作用
- 批准号:
7722315 - 财政年份:2008
- 资助金额:
$ 0.18万 - 项目类别:
CALCIUM-MEDIATED EXOCYTOSIS OF NEUROTRANSMITTER DURING SYNAPTIC TRANSMISSION
突触传递过程中钙介导的神经递质胞吐作用
- 批准号:
7182038 - 财政年份:2005
- 资助金额:
$ 0.18万 - 项目类别:
CALCIUM-MEDIATED EXOCYTOSIS OF NEUROTRANSMITTER DURING SYNAPTIC TRANSMISSION
突触传递过程中钙介导的神经递质胞吐作用
- 批准号:
6975463 - 财政年份:2004
- 资助金额:
$ 0.18万 - 项目类别:
CALCIUM MEDIATED EXOCYTOSIS OF NEUROTRANSMITTER DURING SYNAPTIC TRANSMISSION
突触传递过程中钙介导的神经递质胞吐作用
- 批准号:
6469039 - 财政年份:2001
- 资助金额:
$ 0.18万 - 项目类别:
MULTIPHOTON SCANNING LASER FLUORESCENCE MICROSCOPE
多光子扫描激光荧光显微镜
- 批准号:
6291330 - 财政年份:2001
- 资助金额:
$ 0.18万 - 项目类别:
CALCIUM MEDIATED EXOCYTOSIS OF NEUROTRANSMITTER DURING SYNAPTIC TRANSMISSION
突触传递过程中钙介导的神经递质胞吐作用
- 批准号:
6354290 - 财政年份:2000
- 资助金额:
$ 0.18万 - 项目类别:
CALCIUM MEDIATED EXOCYTOSIS OF NEUROTRANSMITTER DURING SYNAPTIC TRANSMISSION
突触传递过程中钙介导的神经递质胞吐作用
- 批准号:
6220678 - 财政年份:1999
- 资助金额:
$ 0.18万 - 项目类别:
CALCIUM MEDIATED EXOCYTOSIS OF NEUROTRANSMITTER DURING SYNAPTIC TRANSMISSION
突触传递过程中钙介导的神经递质胞吐作用
- 批准号:
6121827 - 财政年份:1999
- 资助金额:
$ 0.18万 - 项目类别:
CALCIUM MEDIATED EXOCYTOSIS OF NEUROTRANSMITTER DURING SYNAPTIC TRANSMISSION
突触传递过程中钙介导的神经递质胞吐作用
- 批准号:
6282140 - 财政年份:1998
- 资助金额:
$ 0.18万 - 项目类别:
CALCIUM MEDIATED EXOCYTOSIS OF NEUROTRANSMITTER DURING SYNAPTIC TRANSMISSION
突触传递过程中钙介导的神经递质胞吐作用
- 批准号:
6252936 - 财政年份:1997
- 资助金额:
$ 0.18万 - 项目类别:
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