PHOSPHORYLATION OF LATE G1 TRANSCRIPTION COMPLEXES IN S CEREVISIAE

这个子项目是众多研究子项目之一

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Late G1-specific transcription is critical for the transition to S phase. This transcription involves at least three proteins: Swi4, Swi6 and Whi5. Whi5 is a repressor that is removed from the complex by Cln3/Cdk phosphorylation. However, there is evidence that S/TP sites in Swi6 are also critical for either removing Whi5 or neutralizing its repressing function. We would like to know if any or all of these sites are phosphorylated in vivo.