REAL TIME FMRI AUGMENTED LEARNED CONTROL OF BRAIN ACTIVATION AND PAIN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 简介： 如果一个人可以学会直接控制大脑中局部区域的激活，这种方法可能会控制调节行为和认知的神经生理机制，并可能为治疗疾病提供不同的途径。对内源性疼痛调节系统的控制是一个特别重要的目标，因为它可以实现对疼痛的临床控制的独特机制。 方法和讨论： 10（2个月：8 F）来自斯坦福大学疼痛管理中心的慢性疼痛患者接受训练，以使用认知策略增加然后减少rACC目标ROI中的脑激活。 在每次13分钟的跑步后，患者对疼痛强度增加与减少条件相比的差异进行定量评级。患者接受2-3次培训，共6次。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: If an individual can learn to directly control activation of localized regions within the brain, this approach might provide control over the neurophysiological mechanisms that mediate behavior and cognition and could potentially provide a different route for treating disease. Control over the endogenous pain modulatory system is a particularly important target because it could enable a unique mechanism for clinical control over pain. Methods and Discussion: 10 (2 M: 8 F) chronic pain patients from the Stanford University Pain Management Center were trained to increase and then to decrease brain activation in the rACC target ROI using cognitive strategies. Following each 13-min run, patients made quantitative ratings of the difference in pain intensity during the increase compared to the decrease conditions. atients received 2-3 training runs/session for 6 sessions.