INTER-SITE QA DEVELOPMENT FOR THE FIRST BIRN

第一个诞生的站点间质量保证开发

• 批准号: 7722865
• 负责人: Gary H Glover
• 金额: $ 1.68万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722865
• 关键词: Biomedical Informatics Research Network; Calibration; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Grant; Institution; Meta-Analysis; Methods; Population; Population Study; Research; Research Personnel; Resources; Schizophrenia; Site; Source; Time; United States National Institutes of Health; Work; hemodynamics; improved; programs; quality assurance

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The FIRST (Functional Imaging Research Schizophrenia Testbed) Biomedical Informatics Research Network (fBIRN) program is the first-ever large scale, multi-center fMRI study of schizophrenia (http://www.nbirn.net). The fBIRN project will pool fMRI data from each of the 11 participating sites to enable the acquisition of a large and diverse study population in a modest time period. Our Center has been responsible for the calibration and quality assurance aspects important for multi-center fMRI trials, and G. Glover chairs the Calibration Working Group within the fBIRN. This subproject is a study of the use of breath holding (BH) to calibrate and mitigate the confounding effects of hemodynamic differences between subjects, thereby reducing variance and improving the ability to pool data across large populations. Previous activities have developed the basic method, which is in current use by the consortium.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 FIRST（Functional Imaging Research Schizophrenia Testbed）Biomedical Informatics Research Network（fBIRN）项目是首个针对精神分裂症的大规模、多中心fMRI研究（http：www.nbirn.net）。fBIRN项目将汇集来自11个参与站点的fMRI数据，以便在适当的时间内获得大量多样化的研究人群。本中心一直负责多中心功能磁共振成像试验的校准和质量保证方面，G。格洛弗在fBIRN内主持校准工作组。 该子项目是一项使用屏气（BH）校准和减轻受试者之间血流动力学差异的混杂效应的研究，从而减少方差并提高在大人群中汇总数据的能力。以前的活动已经制定了基本方法，该集团目前正在使用。