PROTEOMICS CORE

2.A.2.总体目标 蛋白质组学核心旨在为MRDDRC研究人员提供访问最先进的技术的途径 所需的质谱学和微尺度毛细管高效液相色谱(蛋白质组学) 神经发育障碍的细胞和分子生物学的高级研究。格林伯格博士 (该中心主任)将担任核心主任。Jebanathirajah博士，新任助理教授 在儿童医院的神经生物学项目中，以及质谱学领域的专家，将是 负责监督所有核心活动的经理。核心的主要目标将是使用技术 以协助MRDDRC研究人员对具有以下特性的蛋白质复合体进行表征 与神经功能相关，以描述神经系统中蛋白质组成的变化 在发育期间和在导致发育残疾的条件下，并确定和 描述神经元蛋白质的翻译后修饰的功能。蛋白质组学的核心是 积极参与质谱学领域的研究以及任何新开发的工具和方法将 提供给解除武装、复员和复员方案调查人员。核心还将提供和开发与蛋白质组学相关的 统计和数据处理工具。

2.a.2. Overall Objective The Proteomics Core aims to provide MRDDRC investigators with access to state of the art technologies in mass spectrometry and microscale capillary high performance liquid chromatography (proteomics) required for advanced studies in the cell and molecular biology of neurological developmental disabilities. Dr Greenberg (the Director of this MRDDRC) will be the Director of the Core. Dr. Jebanathirajah, a new Assistant Professor in the Neurobiology Program at Children's Hospital, and an expert in the field of mass spectrometry, will be the Manager responsible for supervising all Core activities. Major goals of the Core will be to use the techniques of mass spectrometry to assist MRDDRC investigators in the characterization of protein complexes that are relevant to neuronal function, to characterize changes in protein composition that occur in the nervous system during development and under conditions that lead to developmental disabilities, and to identify and characterize the function of post-translational modification of neuronal proteins. The Proteomics Core is actively involved in research in the area of mass spectrometry and any newly developed tools and methods will be made available to the MRDDRC investigators. The Core will also provide and develop proteomics related statistical and data handling tools.