MOUSE GENETICS SERVICE CORE

小鼠遗传学服务核心

• 批准号: 7699775
• 负责人: Kathleen Joyce Millen
• 金额: $ 21.31万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7699775
• 关键词: Ally; Animal Model; Biological Sciences; Cells; Chicago; Chimera organism; Collaborations; Communities; Complement component C1s; Consultations; Core Facility; Embryo; Equipment; Faculty; Funding; Gene Targeting; Generations; Genetic Engineering; Genetic Services; Genome; Grant; Individual; Laboratory mice; Mental Retardation and Developmental Disabilities Research Centers; Microinjections; Mouse Strains; Mus; Mutagenesis; Neurobiology; Neurologic; Phenotype; Provider; Purpose; Reagent; Research; Research Personnel; Services; Technology; Transgenic Animals; Transgenic Mice; Transgenic Organisms; Universities; cost; design; embryonic stem cell; member; mouse model; programs; tool; vector

The mouse Genetic services aspect of this Model Organisms Core is widely used core service by MRDDRC investigators and serves an essential service to the MRDD community. The MRDDRC will partner with the existing Biological Sciences Divisional Core to provide transgenic and targeted mutagenesis services to MRDDRC investigators. By partnering with the existing Divisional core, the MRDDRC grant strengthens the already successful core. MRDDRC investigators will gain a subsidy services through this core. MRDDRC funding of the divisional core also allows the addition of ES cell culturing services and gene targeting - services not currently available in the Divisional Mouse Core. Further, the MRDDRC investigators will have available the expertise of both MRDDRC co-directors - both accomplished mouse geneticists with extensive neurobiological expertise. The co-directors will provide project design consultation, vector design expertise and advice for analysis. The co-directors are familiar with the research programs of all MRDDRC users and can facilitate interactions between investigators for reagent sharing and collaborations for further analysis. The codirectors will also refer users to other MRDDRC cores for additional analysis of mouse models generated, including the new Mouse Phenotyping Subcore.

该模式生物核心的小鼠遗传服务方面是广泛使用的核心服务， MRDDRC调查并为MRDD社区提供基本服务。MRDDRC将与 与现有的生物科学部门核心，提供转基因和靶向诱变服务 调查人员的报告通过与现有的司核心合作，该基金的赠款加强了 成功的核心MRDDRC调查人员将通过这一核心获得补贴服务。MRDDRC 该部门的核心资金还允许增加ES细胞培养服务和基因靶向- 分区鼠标核心目前没有提供的服务。此外，MRDDRC调查人员将 提供MRDDRC共同主任的专业知识-都是完成小鼠遗传学家，具有广泛的 神经生物学专业知识。共同主任将提供项目设计咨询，矢量设计专业知识， 分析建议。共同主任熟悉所有MRDDRC用户的研究计划， 促进研究者之间的互动，以共享试剂和合作进行进一步分析。联合主任 还将向用户推荐其他MRDDRC核心，以进一步分析生成的小鼠模型， 包括新的小鼠表型分型子核心。