ACTG 362:LONG-TERM ASSESSMENT FOR METABOLIC, CARDIOVASCULAR AND NEUROLOGIC COMP

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 艾滋病临床试验小组研究362是一项多中心的长期自然病史研究，旨在评估在接受抗逆转录病毒治疗的受试者中，过去的CD4细胞计数为50个/毫米~3的受试者的代谢、心血管和神经并发症。 ACTG 362的主要目标是： 心血管/代谢：检测长期抗逆转录病毒治疗(ART)受试者中高血压、胰岛素抵抗、空腹血糖异常和代谢综合征的发生率和患病率，以及随时间的变化。 机会性感染：检查机会性感染的发生率，描述其临床表现，并将其发生率和临床表现与免疫重建和病毒学控制的标志相关联。 神经学：通过筛查神经心理学和神经学检查，检查认知障碍和周围神经病的发生率和患病率，以及这些指标随时间的变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. AIDS Clinical Trials Group Study 362 is a multicenter, long-term natural history study to assess metabolic, cardiovascular, and neurologic complications in subjects with a past CD4 count <50 cells/mm3 who increased to >100 cells/mm3 on antiretroviral therapy. The primary objectives for ACTG 362 are: Cardiovascular/Metabolic: to examine the incidence and prevalence, and changes over time of hypertension, insulin resistance, abnormal fasting glucose, and the metabolic syndrome in subjects on long-term antiretroviral therapy (ART). Opportunistic Infections: to examine the incidence of opportunistic infections, describe their clinical presentations, and correlate their incidence and clinical presentations with markers of immune reconstitution and virological control. Neurology: to examine the incidence and prevalence, and changes in these measures over time, of cognitive impairment and peripheral neuropathy as ascertained by a screening neuropsychologic and neurologic examination.