Weill Cornell Medicine - Rutgers New Jersey Medical School Clinical Trials Unit

项目总结 威尔康奈尔医学-罗格斯新泽西医学院临床试验单位(WCM-NJMS CTU)将 开展国家过敏和传染病研究所(NIAID)赞助的艾滋病毒网络研究 治疗和艾滋病毒预防；从纽约市(NYC)的不同社区招募参与者- 纽瓦克大都会地区，美国艾滋病毒流行的震中--居住着14%的美国人 感染艾滋病毒；并为网络的科学议程作出贡献。该股由一个中央核心设施和 三个临床研究站点(CRS)。WCM-NJMS CTU为这三个组织提供中央研究支持 CRSS，包括调查和实验室监督、财务管理、质量保证、培训和 社区参与。三个CRSS，WCM-Uptown，WCM-切尔西和罗格斯NJMS，位于 纽约市-纽瓦克大都市区的不同部分，服务于不同的种族和民族多样性 艾滋病毒携带者或高危人群。WCM-Uptown CRS位于哈莱姆区附近，有 一些社区的艾滋病毒血清阳性率超过5%。WCM-切尔西CRS位于 在切尔西，一些社区的血清阳性率在纽约市最高，超过8%。这个 罗格斯NJMS CRS位于纽瓦克的中心，服务的人口主要是非裔美国人 女性比例很高，一些社区的艾滋病毒血清阳性率超过 5%。WCM-NJMS CTU调查人员是该领域的领导者，他们正在塑造艾滋病毒的治疗和艾滋病毒 预防研究议程。他们在艾滋病毒治疗策略、抗逆转录病毒方面经验丰富 药物和治疗策略、结核病和艾滋病毒共病，包括肝炎和神经病学 并发症以及艾滋病毒预防战略，包括艾滋病毒暴露前预防(PrEP)和 综合战略。社区参与是WCM-NJMS CTU的一个关键优势，既有现场特定的 和联合社区咨询委员会(CAB)，以及有效沟通研究结果的良好记录 回到社区。CTU的三个CRSS已经成功地将1000多名参与者纳入了一个 本赠款周期内各种艾滋病毒治疗和预防试验，保留情况和数据尚待解决 质量。此外，反恐组调查人员在科学和领导方面为 网络。总而言之，WCM-NJMS CTU汇集了一批公认调查员 将与经验丰富的临床研究人员合作进行尖端艾滋病毒治疗和 纽约-纽瓦克大都会地区的艾滋病毒预防研究。

PROJECT SUMMARY The Weill Cornell Medicine – Rutgers New Jersey Medical School Clinical Trials Unit (WCM-NJMS CTU) will conduct National Institute of Allergy and Infectious Diseases (NIAID)-sponsored network studies of HIV treatment and HIV prevention; enroll participants from the diverse communities of the New York City (NYC)- Newark metropolitan area, the epicenter of the HIV epidemic in the U.S. -- home to 14% of Americans living with HIV; and contribute to the networks' scientific agendas. The unit consists of a central core facility and three clinical research sites (CRS). The WCM-NJMS CTU provides central research support to the three CRSs, including investigative and laboratory oversight, financial administration, quality assurance, training, and community engagement. The three CRSs, WCM-Uptown, WCM-Chelsea, and Rutgers NJMS, are located in different parts of the NYC-Newark metropolitan area and serve distinct, racially and ethnically diverse populations of people living with or at-risk for HIV. The WCM-Uptown CRS is located close to Harlem, with some neighborhoods demonstrating HIV seroprevalence rates of over 5%. The WCM-Chelsea CRS is located in Chelsea, with some neighborhoods demonstrating the highest seroprevalence rate in NYC of over 8%. The Rutgers NJMS CRS is located in the center of Newark, serving a predominately African American population with a high proportion of women, with some neighborhoods demonstrating an HIV seroprevalence rate of over 5%. WCM-NJMS CTU investigators are leaders in the field who are shaping the HIV treatment and HIV prevention research agendas. They are highly experienced with expertise in HIV cure strategies, antiretroviral drugs and treatment strategies, tuberculosis, and HIV comordibidities, including hepatitis and neurologic complications as well as HIV prevention strategies, including HIV pre-exposure prophylaxis (PrEP) and integrated strategies. Community engagement is a key strength of the WCM-NJMS CTU with both site-specific and joint Community Advisory Boards (CABs) and a strong record of effectively communicating study results back to the community. The CTU's three CRSs have successfully enrolled over 1000 participants into a wide variety of HIV treatment and prevention trials during the current grant cycle with outstanding retention and data quality. Furthermore, CTU investigators have made substantive scientific and leadership contributions to the networks. In summary, the WCM-NJMS CTU brings together a diverse group of recognized investigator leaders who will work with an experienced clinical research staff to conduct cutting-edge HIV treatment and HIV prevention studies in the NYC-Newark metropolitan areas.