CAN WE FACILITATE CONSCIOUSNESS AFTER SEVERE TRAUMATIC BRAIN INJURY?

严重脑外伤后我们可以促进意识吗？

• 批准号: 7604295
• 负责人: Theresa L Bender Pape
• 金额: $ 9.87万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604295
• 关键词: FACILITATE; CONSCIOUSNESS; AFTER; SEVERE; TRAUMATIC

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The standard medical treatment and rehabilitation provided to persons incurring a severe brain injury is based largely on case studies. There is no known treatment that facilitates recovery for persons who remain unconscious after severe traumatic brain injury. The purpose of this Phase I clinical trial is to examine the safety and efficacy of the experimental treatment, repetitive transcranial magnetic stimulation (rTMS), during coma recovery. The objectives are to: 1) Determine whether rTMS presented within parameters known to be safe on the healthy brain are also tolerated on the severely injured brain, and 2) Examine the potential of rTMS to induce a state conducive to neural plasticity, and 3) Identify the TMS parameters most effective in facillitating clinical recovery as well as the recovery of consciousness. The rationale for suggesting that rTMS will induce a state conducive to neural plasticity and/or induce neural adaptation is that pre-clinical evidence suggests that it influences brain plasticity and reorganization via neuronal excitation and inhibition.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 为遭受严重脑损伤的人提供的标准医疗和康复主要以个案研究为基础。目前还没有已知的治疗方法可以促进严重创伤性脑损伤后仍处于昏迷状态的人的康复。 这项I期临床试验的目的是检查昏迷恢复期间重复经颅磁刺激(RTMS)这一实验性治疗的安全性和有效性。目标是： 1)确定在已知对健康大脑安全的参数范围内出现的rTMS在严重损伤的大脑中是否也被容忍，以及 2)检测rTMS诱导有利于神经可塑性的状态的潜力，以及 3)确定对促进临床恢复和意识恢复最有效的TMS参数。 提示rTMS将诱导一种有利于神经可塑性和/或诱导神经适应的状态的基本原理是，临床前证据表明，它通过神经元的兴奋和抑制影响大脑的可塑性和重组。