EFFECT OF LOW CARBOHYDRATE DIET ON SYMPTOMS OF IBS: A PROSPECTIVE PILOT STUDY

低碳水化合物饮食对 IBS 症状的影响：一项前瞻性试点研究

• 批准号: 7625631
• 负责人: DOUGLAS A DROSSMAN
• 金额: $ 3.58万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7625631
• 关键词: Abdominal Pain; Body Weight decreased; Carbohydrates; Computer Retrieval of Information on Scientific Projects Database; Daily; Diarrhea; Diet; Eligibility Determination; Enrollment; Feces; Fiber; Frequencies; Funding; Grant; Hydroxyindoleacetic Acid; Institution; Irritable Bowel Syndrome; Lead; Outcome Measure; Participant; Patient Care; Patients; Physiological; Pilot Projects; Purpose; Quality of life; Research; Research Personnel; Resources; Role; Serotonin; Severities; Source; Symptoms; United States National Institutes of Health; Week; daily functioning; diaries; gastrointestinal symptom; improved; indexing; prospective; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our purpose is to prospectively determine 1) the effect of a very low carbohydrate diet on quality of life and gastrointestinal symptoms in patients with diarrhea-predominant irritable bowel syndrome (IBS-D); and 2) to determine possible physiological correlates of symptom improvement, as related to post-prandial 5-HT and 5-HIAA release, weight loss and fiber content. These expected findings could lead to a better understanding of the role of diet in IBS and may ultimately help improve patient care. Thirty volunteers will be enrolled at UNC-CH. An index of IBS severity will be used to determine eligibility. All participants will be given two weeks of meals for a carbohydrate-rich diet, followed by four weeks of a very low carbohydrate diet. Outcome measures will include symptoms (standardized abdominal pain, stool form and frequency) using daily diary cards, daily function status, patient quality of life, and post-prandial release of 5-HT and 5-HIAA.

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