PREVALENCE OF EGG ABNORMALITIES IN THE FUNCTIONAL GI DISORDERS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 胃电图（EGG）是胃的内在电活动的量度，反映胃起搏器的作用。 先前的研究已经显示异常EGG模式（例如，胃动过缓或胃动过速或两者）与某些病症（例如，消化不良、胃轻瘫）或症状（例如，恶心或呕吐）。 最近的一项研究也表明，肠易激综合征患者中，胃电图异常的比例很高。 一般而言，EGG数据来自于小规模的临床人群，关于这些和其他疾病的EGG异常患病率或EGG异常与症状严重程度的相关性的信息有限。 为了将我们对EGG的理解与临床相关性结合起来，我们建议：a）确定哪些临床人群更可能有EGG异常，以及B）确定EGG异常是否与症状严重程度相关。 因此，通过这项研究，我们将了解EGG的临床实用性：作为某些症状或病症的生理标志物，以及评估临床反应的措施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Electrogastrogram (EGG) is a measure of the intrinsic electrical activity of the stomach, reflecting the action of the gastric pacemaker. Previous studies have shown an association of abnormal EGG patterns (e.g. bradygastria or tachygastria or both) with certain conditions (e.g. dyspepsia, gastroparesis) or symptoms (e.g., nausea or vomiting). One recent study also showed a high proportion of EGG abnormalities among patients with irritable bowel syndrome. In general, data on EGG has been obtained from small select clinical populations, and there is limited information with regard to the prevalence of EGG abnormalities with these and other conditions, or the association of EGG abnormalities with symptom severity. To bring our understanding of the EGG into clinical relevance, we propose to: a) identify which clinical popoulations are more likely to have EGG abnormalities, and b) determine whether EGG abnormalities correlate with symptom severity. Thus, with this study, we would have information on the clinical utility of EGG: as a physiological marker for certain symptoms or conditions and as a measure to assess clinical response.