PREVALENCE OF EGG ABNORMALITIES IN THE FUNCTIONAL GI DISORDERS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Electrogastrogram (EGG) is a measure of the intrinsic electrical activity of the stomach, reflecting the action of the gastric pacemaker. Previous studies have shown an association of abnormal EGG patterns (e.g. bradygastria or tachygastria or both) with certain conditions (e.g. dyspepsia, gastroparesis) or symptoms (e.g., nausea or vomiting). One recent study also showed a high proportion of EGG abnormalities among patients with irritable bowel syndrome. In general, data on EGG has been obtained from small select clinical populations, and there is limited information with regard to the prevalence of EGG abnormalities with these and other conditions, or the association of EGG abnormalities with symptom severity. To bring our understanding of the EGG into clinical relevance, we propose to: a) identify which clinical popoulations are more likely to have EGG abnormalities, and b) determine whether EGG abnormalities correlate with symptom severity. Thus, with this study, we would have information on the clinical utility of EGG: as a physiological marker for certain symptoms or conditions and as a measure to assess clinical response.