STUDY OF DIETARY CHANGES IN THE TREATMENT OF PEDIATRIC FATTY LIVER DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 非酒精性脂肪性肝病(NAFLD)是一种与肥胖相关的慢性肝病，在25%的肥胖儿童中发现。目前，无论是儿童还是成人，都没有有效的治疗方法来治疗NAFLD。果糖是一种碳水化合物，在美国人的饮食中以高果糖玉米糖浆和果汁饮料的形式大量存在。在动物模型中，果糖代谢已被证明会导致内脏肥胖、胰岛素抵抗以及NAFLD。30名因ALT升高而确诊为NAFLD的肥胖儿童将被随机分为两组。I组将接受饮食建议，避免高果糖玉米糖浆和果汁。第二组将接受传统低脂饮食的咨询。将鼓励所有儿童增加锻炼，减少久坐行为。主要结果变量将是ALT的降低。其他次要结果指标包括体重指数、蛋氨酸呼气试验水平、蛋氨酸代谢物水平、空腹胰岛素和血糖、脂联素、骨桥蛋白、Th1和Th2细胞因子水平。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Nonalcoholic fatty liver disease (NAFLD), is an obesity related chronic liver disease found in up to 25% of obese children. Currently there is not an effective treatment for NAFLD in either children or adults. Fructose is a carbohydrate that is found in large amounts in the American diet in the form of high fructose corn syrup and fruit juice based beverages. Fructose metabolism has been shown to induce visceral obesity and insulin resistance as well as NAFLD in animal models. Thirty obese children with NAFLD as identified by elevated ALT will be randomized to two treatment groups. Group I will be counseled with a diet avoiding high fructose corn syrup and fruit juice. Group II will be counseled with a traditional low fat diet. All children will be encouraged to increase exercise and decrease sedentary behavior. Primary outcome variable will be decrease in ALT. Other secondary outcome measures will include BMI, methinonine breath test levels, methionine metabolite levels, fasting insulin and glucose, adiponectin, osteopontin, Th1 and Th2 cytokine levels.