STUDY OF DIETARY CHANGES IN THE TREATMENT OF PEDIATRIC FATTY LIVER DISEASE

饮食改变治疗小儿脂肪肝的研究

• 批准号: 7604315
• 负责人: PETER Frank WHITINGTON
• 金额: $ 0.87万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604315
• 关键词: STUDY; DIETARY; CHANGES; TREATMENT; PEDIATRIC

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Nonalcoholic fatty liver disease (NAFLD), is an obesity related chronic liver disease found in up to 25% of obese children. Currently there is not an effective treatment for NAFLD in either children or adults. Fructose is a carbohydrate that is found in large amounts in the American diet in the form of high fructose corn syrup and fruit juice based beverages. Fructose metabolism has been shown to induce visceral obesity and insulin resistance as well as NAFLD in animal models. Thirty obese children with NAFLD as identified by elevated ALT will be randomized to two treatment groups. Group I will be counseled with a diet avoiding high fructose corn syrup and fruit juice. Group II will be counseled with a traditional low fat diet. All children will be encouraged to increase exercise and decrease sedentary behavior. Primary outcome variable will be decrease in ALT. Other secondary outcome measures will include BMI, methinonine breath test levels, methionine metabolite levels, fasting insulin and glucose, adiponectin, osteopontin, Th1 and Th2 cytokine levels.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 非酒精性脂肪肝病 (NAFLD) 是一种与肥胖相关的慢性肝病，高达 25% 的肥胖儿童患有此病。 目前，无论是儿童还是成人，都没有有效的 NAFLD 治疗方法。 果糖是一种碳水化合物，在美国饮食中以高果糖玉米糖浆和果汁饮料的形式大量存在。 在动物模型中，果糖代谢已被证明会诱发内脏肥胖、胰岛素抵抗以及 NAFLD。 30 名通过 ALT 升高确定患有 NAFLD 的肥胖儿童将被随机分为两个治疗组。 第一组将被建议饮食避免高果糖玉米糖浆和果汁。 第二组将接受传统低脂饮食的建议。 我们将鼓励所有儿童增加锻炼并减少久坐行为。 主要结果变量是 ALT 降低。 其他次要结果指标包括 BMI、甲硫氨酸呼气测试水平、甲硫氨酸代谢物水平、空腹胰岛素和血糖、脂联素、骨桥蛋白、Th1 和 Th2 细胞因子水平。