Statistical methods to understand changes in dietary patterns over time and cardiovascular disease risk among understudied populations

了解受研究人群饮食模式随时间变化和心血管疾病风险的统计方法

• 批准号: 10571108
• 负责人: Briana Joy Kennedy Stephenson
• 金额: $ 16.19万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10571108
• 关键词: Address; Adherence; Adult; Age; Attention; Award; Behavior; Beverages; Biometry; Black race; COVID-19 pandemic; Cardiovascular Diseases; Cessation of life; Clinical; Cohort Studies; Communities; Computer software; Consumption; Data; Dependence; Development; Diabetes Mellitus; Diet; Dietary Assessment; Dietary Component; Dietary Practices; Dietary intake; Disparity; Educational workshop; Elements; Epidemiology; Ethnic Origin; Ethnic Population; Event; Female; Food; Foundations; Funding; Future; Goals; Health; Hispanic; Hypertension; Incidence; Individual; Interdisciplinary Study; Intervention; Lead; Longitudinal Studies; Measures; Methodology; Methods; Modeling; Nurses; Nurses' Health Study; Nutrient; Nutrition Policy; Nutritional; Nutritional Study; Obesity; Outcome; Pattern; Policies; Population; Population Heterogeneity; Race; Recommendation; Research; Research Activity; Research Design; Research Personnel; Risk; Risk Estimate; Risk Factors; Role; Socioeconomic Factors; Statistical Methods; Subgroup; Techniques; Time; Training; Training Activity; Unhealthy Diet; United States; United States National Institutes of Health; Vocational Guidance; Vulnerable Populations; Woman; Women' s Health; aged; black women; cardiometabolic risk; cardiometabolism; cardiovascular disorder epidemiology; cardiovascular disorder risk; cardiovascular health; cohort; dietary; disease disparity; experience; health disparity; health equity; high dimensionality; high risk; improved; innovation; insight; marginalization; method development; mortality; nutrition; nutritional epidemiology; population based; population health; programs; skills; software development; symposium; time use; usability

PROJECT SUMMARY My goal is to establish myself as an independent researcher on cardiovascular disease (CVD) disparities with expertise in Bayesian nonparametric clustering techniques and nutrition epidemiology. Attaining these objectives will require focused didactic training and research guidance. My research goals are to develop new methodology to identify temporal dietary patterns that are related to CVD risk of understudied and marginalized subgroups. These new methods will identify dietary exposure differences that occur across populations in the United States over time that otherwise may be overlooked. I will also develop methods to assess how these temporal dietary exposure patterns impact CVD risk outcomes for adult women. With access to two NIH- funded female cohort studies—the Black Women’s Health Study and the Nurses’ Health Study II —I will apply the proposed methods to examine multivariate dietary exposure changes of US women over time and their association with CVD health disparities, highlighting differences defined by racial/ethnic subpopulations. Through implementation of the proposed methods and application to two large population-based cohorts, this research will characterize the dietary behaviors of subgroups at greatest risk of CVD disparities and inform future policies to improve dietary recommendations and promote population health equity. To achieve my training goals, the proposed training plan consists of four elements: (1) a didactic component to expand my expertise in nutrition and CVD epidemiology and disparities; (2) career guidance in methodological development in repeated measures analysis of nutritional data of large, diverse populations; (3) innovative research using gained content expertise in nutrition and CVD epidemiology and previous statistical training; and (4) exchange of ideas in biostatistics, nutrition epidemiology, and CVD disparities through attendance at conferences, seminars, and workshops. Planned training activities will enhance my understanding of dietary consumption behaviors, CVD epidemiology, and disparities enabling me to develop useful models to measure multivariate dietary exposure patterns over time and CVD risk estimation for vulnerable populations. The skills and experience developed during this award period will prepare me to lead an interdisciplinary research program addressing factors associated with cardiometabolic health disparities.

项目摘要 我的目标是确立自己的心血管疾病（CVD）分布的独立研究人员 贝叶斯非参数聚类技术和营养流行病学方面的专业知识。达到这些 目标将需要集中的教学培训和研究指导。我的研究目标是开发新的 识别与CVD风险相关的临时饮食模式的方法论 亚组。这些新方法将确定饮食暴露的差异 随着时间的流逝，美国可能会被忽略。我还将开发方法来评估这些方法 临时饮食暴露模式会影响成年女性的CVD风险结果。访问两个NIH- 资助的女队列研究 - 黑人妇女的健康研究和护士健康研究II-我将适用 提出的方法是检查美国女性随着时间及其她们的多变量饮食暴露变化及其 与CVD健康差异相关，突出了由种族/种族亚群定义的差异。 通过实施拟议的方法并应用于两个大型基于人群的同伙，这 研究将表征亚组的饮食行为，最大的CVD差异风险并告知 未来改善饮食建议并促进人口健康公平的政策。实现我的 培训目标，拟议的培训计划包括四个要素：（1）扩展我的教学成分 营养和CVD流行病学和差异方面的专业知识； （2）方法论的职业指导 在重复测量大型，潜水员种群的营养数据的重复测量中发展； （3）创新 使用在营养和CVD流行病学和以前的统计培训方面获得的内容专业知识的研究； （4）通过出席的生物统计学，营养流行病学和CVD差异的思想交流 会议，半手和讲习班。计划的培训活动将增强我对饮食的理解 消费行为，CVD流行病学和差异，使我能够开发有用的模型来衡量 随着时间的推移，多元饮食暴露模式和脆弱人群的CVD风险估计。技能 并在此奖励期间开发的经验将使我为领导跨学科研究做好准备 程序解决与心脏代谢健康差异相关的因素。